The Full Wiki

More info on POU4F3

POU4F3: Wikis


Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.


From Wikipedia, the free encyclopedia

POU domain, class 4, transcription factor 3
Symbols POU4F3; BRN3C; DFNA15; MGC138412
External IDs OMIM602460 MGI102523 HomoloGene2023 GeneCards: POU4F3 Gene
RNA expression pattern
PBB GE POU4F3 208554 at tn.png
More reference expression data
Species Human Mouse
Entrez 5459 18998
Ensembl ENSG00000091010 ENSMUSG00000024497
UniProt Q15319 Q63955
RefSeq (mRNA) NM_002700 NM_138945
RefSeq (protein) NP_002691 NP_620395
Location (UCSC) Chr 5:
145.7 - 145.7 Mb
Chr 18:
42.52 - 42.52 Mb
PubMed search [1] [2]

POU domain, class 4, transcription factor 3 is a protein that in humans is encoded by the POU4F3 gene.[1][2]


  1. ^ Vahava O, Morell R, Lynch ED, Weiss S, Kagan ME, Ahituv N, Morrow JE, Lee MK, Skvorak AB, Morton CC, Blumenfeld A, Frydman M, Friedman TB, King MC, Avraham KB (Apr 1998). "Mutation in transcription factor POU4F3 associated with inherited progressive hearing loss in humans". Science 279 (5358): 1950-4. PMID 9506947.  
  2. ^ "Entrez Gene: POU4F3 POU domain, class 4, transcription factor 3".  

Further reading

  • Nolan LS, Jagutpal SS, Cadge BA, et al. (2007). "Identification and functional analysis of common sequence variants in the DFNA15 gene, Brn-3c.". Gene 400 (1-2): 89–97. doi:10.1016/j.gene.2007.05.023. PMID 17611044.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Clough RL, Sud R, Davis-Silberman N, et al. (2004). "Brn-3c (POU4F3) regulates BDNF and NT-3 promoter activity.". Biochem. Biophys. Res. Commun. 324 (1): 372–81. doi:10.1016/j.bbrc.2004.09.074. PMID 15465029.  
  • Weiss S, Gottfried I, Mayrose I, et al. (2003). "The DFNA15 deafness mutation affects POU4F3 protein stability, localization, and transcriptional activity.". Mol. Cell. Biol. 23 (22): 7957–64. doi:10.1128/MCB.23.22.7957-7964.2003. PMID 14585957.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Leonard JH, Cook AL, Van Gele M, et al. (2002). "Proneural and proneuroendocrine transcription factor expression in cutaneous mechanoreceptor (Merkel) cells and Merkel cell carcinoma.". Int. J. Cancer 101 (2): 103–10. doi:10.1002/ijc.10554. PMID 12209986.  
  • Erkman L, McEvilly RJ, Luo L, et al. (1996). "Role of transcription factors Brn-3.1 and Brn-3.2 in auditory and visual system development.". Nature 381 (6583): 603–6. doi:10.1038/381603a0. PMID 8637595.  
  • Xiang M, Zhou L, Macke JP, et al. (1995). "The Brn-3 family of POU-domain factors: primary structure, binding specificity, and expression in subsets of retinal ganglion cells and somatosensory neurons.". J. Neurosci. 15 (7 Pt 1): 4762–85. PMID 7623109.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



Got something to say? Make a comment.
Your name
Your email address