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From Wikipedia, the free encyclopedia

POU (pronounced 'pow') is a family of proteins that have well-conserved homeodomains.[1]

Contents

Function

POU proteins are eukaryotic transcription factors containing a bipartite DNA binding domain referred to as the POU domain.

The various members of the POU family have a wide variety of functions, all of which are related to the development of an organism.

Etymology

The acronym POU is derived from the names of three mammalian transcription factors:

Diversity

POU domain genes have been described in organisms as divergent as Caenorhabditis elegans, Drosophila, Xenopus, zebrafish and human but have not been yet identified in plants and fungi.

D'Souza et al. (PNAS, 91:9397-9401. 1994) demonstrated a surprisingly high degree of amino acid sequence conservation (37%-42%) of POU homeodomains to the transcriptional regulator comS from the gram positive prokaryote Bacillus subtilis. Interestingly, akin to the way that POU homeodomain regulators lead to tissue differentiation in metazoans, this transcription factor is critical for differentation of a subpopulation of B. subtilis into a state of genetic competence.

Human genes

Internal links HUGO gene name links
POU1F1 POU1F1
POU2F1, POU2F2, POU2F3 POU2F1, POU2F2, POU2F3
POU3F1, POU3F2, POU3F3, POU3F4 POU3F1, POU3F2, POU3F3, POU3F4
POU4F1, POU4F2, POU4F3 POU4F1, POU4F2, POU4F3
POU5F1 POU5F1
POU6F1, POU6F2 POU6F1, or Haroon POU6F2 or Haroon

References

  1. ^ Phillips K, Luisi B (2000). "The virtuoso of versatility: POU proteins that flex to fit". J. Mol. Biol. 302 (5): 1023–39. doi:10.1006/jmbi.2000.4107. PMID 11183772.  

External links

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