The Full Wiki

More info on PPARGC1B



Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.


From Wikipedia, the free encyclopedia

Peroxisome proliferator-activated receptor gamma, coactivator 1 beta
Symbols PPARGC1B; PERC; PGC-1(beta); PGC1B
External IDs OMIM608886 MGI2444934 HomoloGene15776 GeneCards: PPARGC1B Gene
Species Human Mouse
Entrez 133522 170826
Ensembl ENSG00000155846 ENSMUSG00000033871
UniProt Q86YN6 Q8VHJ7
RefSeq (mRNA) NM_133263 NM_133249
RefSeq (protein) NP_573570 NP_573512
Location (UCSC) Chr 5:
149.09 - 149.21 Mb
Chr 18:
61.42 - 61.53 Mb
PubMed search [1] [2]

Peroxisome proliferator-activated receptor gamma coactivator 1-beta is a protein that in humans is encoded by the PPARGC1B gene.[1][2][3]


See also


  1. ^ Ek J, Andersen G, Urhammer SA, Gaede PH, Drivsholm T, Borch-Johnsen K, Hansen T, Pedersen O (Jan 2002). "Mutation analysis of peroxisome proliferator-activated receptor-gamma coactivator-1 (PGC-1) and relationships of identified amino acid polymorphisms to Type II diabetes mellitus". Diabetologia 44 (12): 2220-6. doi:10.1007/s001250100032. PMID 11793024.  
  2. ^ Kressler D, Schreiber SN, Knutti D, Kralli A (Apr 2002). "The PGC-1-related protein PERC is a selective coactivator of estrogen receptor alpha". J Biol Chem 277 (16): 13918-25. doi:10.1074/jbc.M201134200. PMID 11854298.  
  3. ^ "Entrez Gene: PPARGC1B peroxisome proliferator-activated receptor gamma, coactivator 1 beta".  

External links

Further reading

  • Handschin C, Spiegelman BM (2007). "Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolism.". Endocr. Rev. 27 (7): 728–35. doi:10.1210/er.2006-0037. PMID 17018837.  
  • Esterbauer H, Oberkofler H, Krempler F, Patsch W (2000). "Human peroxisome proliferator activated receptor gamma coactivator 1 (PPARGC1) gene: cDNA sequence, genomic organization, chromosomal localization, and tissue expression.". Genomics 62 (1): 98–102. doi:10.1006/geno.1999.5977. PMID 10585775.  
  • Knutti D, Kaul A, Kralli A (2000). "A tissue-specific coactivator of steroid receptors, identified in a functional genetic screen.". Mol. Cell. Biol. 20 (7): 2411–22. doi:10.1128/MCB.20.7.2411-2422.2000. PMID 10713165.  
  • Lin J, Puigserver P, Donovan J, et al. (2002). "Peroxisome proliferator-activated receptor gamma coactivator 1beta (PGC-1beta ), a novel PGC-1-related transcription coactivator associated with host cell factor.". J. Biol. Chem. 277 (3): 1645–8. doi:10.1074/jbc.C100631200. PMID 11733490.  
  • Lacquemant C, Chikri M, Boutin P, et al. (2002). "No association between the G482S polymorphism of the proliferator-activated receptor-gamma coactivator-1 (PGC-1) gene and Type II diabetes in French Caucasians.". Diabetologia 45 (4): 602–3; author reply 604. doi:10.1007/s00125-002-0783-z. PMID 12032643.  
  • Hara K, Tobe K, Okada T, et al. (2003). "A genetic variation in the PGC-1 gene could confer insulin resistance and susceptibility to Type II diabetes.". Diabetologia 45 (5): 740–3. doi:10.1007/s00125-002-0803-z. PMID 12107756.  
  • Huss JM, Kopp RP, Kelly DP (2002). "Peroxisome proliferator-activated receptor coactivator-1alpha (PGC-1alpha) coactivates the cardiac-enriched nuclear receptors estrogen-related receptor-alpha and -gamma. Identification of novel leucine-rich interaction motif within PGC-1alpha.". J. Biol. Chem. 277 (43): 40265–74. doi:10.1074/jbc.M206324200. PMID 12181319.  
  • Hentschke M, Süsens U, Borgmeyer U (2003). "PGC-1 and PERC, coactivators of the estrogen receptor-related receptor gamma.". Biochem. Biophys. Res. Commun. 299 (5): 872–9. doi:10.1016/S0006-291X(02)02753-5. PMID 12470660.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Shiraki T, Sakai N, Kanaya E, Jingami H (2003). "Activation of orphan nuclear constitutive androstane receptor requires subnuclear targeting by peroxisome proliferator-activated receptor gamma coactivator-1 alpha. A possible link between xenobiotic response and nutritional state.". J. Biol. Chem. 278 (13): 11344–50. doi:10.1074/jbc.M212859200. PMID 12551939.  
  • Hammarstedt A, Jansson PA, Wesslau C, et al. (2003). "Reduced expression of PGC-1 and insulin-signaling molecules in adipose tissue is associated with insulin resistance.". Biochem. Biophys. Res. Commun. 301 (2): 578–82. doi:10.1016/S0006-291X(03)00014-7. PMID 12565902.  
  • Meirhaeghe A, Crowley V, Lenaghan C, et al. (2003). "Characterization of the human, mouse and rat PGC1 beta (peroxisome-proliferator-activated receptor-gamma co-activator 1 beta) gene in vitro and in vivo.". Biochem. J. 373 (Pt 1): 155–65. doi:10.1042/BJ20030200. PMID 12678921.  
  • Patti ME, Butte AJ, Crunkhorn S, et al. (2003). "Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1.". Proc. Natl. Acad. Sci. U.S.A. 100 (14): 8466–71. doi:10.1073/pnas.1032913100. PMID 12832613.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Ling C, Poulsen P, Carlsson E, et al. (2004). "Multiple environmental and genetic factors influence skeletal muscle PGC-1alpha and PGC-1beta gene expression in twins.". J. Clin. Invest. 114 (10): 1518–26. doi:10.1172/JCI200421889. PMID 15546003.  
  • Andersen G, Wegner L, Yanagisawa K, et al. (2006). "Evidence of an association between genetic variation of the coactivator PGC-1beta and obesity.". J. Med. Genet. 42 (5): 402–7. doi:10.1136/jmg.2004.026278. PMID 15863669.  
  • Staiger H, Staiger K, Haas C, et al. (2005). "Fatty acid-induced differential regulation of the genes encoding peroxisome proliferator-activated receptor-gamma coactivator-1alpha and -1beta in human skeletal muscle cells that have been differentiated in vitro.". Diabetologia 48 (10): 2115–8. doi:10.1007/s00125-005-1895-z. PMID 16132959.  
  • Wirtenberger M, Tchatchou S, Hemminki K, et al. (2006). "Associations of genetic variants in the estrogen receptor coactivators PPARGC1A, PPARGC1B and EP300 with familial breast cancer.". Carcinogenesis 27 (11): 2201–8. doi:10.1093/carcin/bgl067. PMID 16704985.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



Got something to say? Make a comment.
Your name
Your email address