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PR domain containing 2, with ZNF domain
Identifiers
Symbols PRDM2; HUMHOXY1; MTB-ZF; RIZ; RIZ1; RIZ2
External IDs OMIM601196 MGI107628 HomoloGene40822 GeneCards: PRDM2 Gene
RNA expression pattern
PBB GE PRDM2 203056 s at tn.png
PBB GE PRDM2 216433 s at tn.png
PBB GE PRDM2 203057 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 7799 110593
Ensembl ENSG00000116731 ENSMUSG00000057637
UniProt Q13029 n/a
RefSeq (mRNA) NM_001007257 XM_898822
RefSeq (protein) NP_001007258 XP_903915
Location (UCSC) Chr 1:
13.9 - 14.02 Mb
Chr 4:
142.4 - 142.45 Mb
PubMed search [1] [2]

PR domain zinc finger protein 2 is a protein that in humans is encoded by the PRDM2 gene.[1][2]

This tumor suppressor gene is a member of a nuclear histone/protein methyltransferase superfamily. It encodes a zinc finger protein that can bind to retinoblastoma protein, estrogen receptor, and the TPA-responsive element (MTE) of the heme-oxygenase-1 gene. Although the functions of this protein have not been fully characterized, it may (1) play a role in transcriptional regulation during neuronal differentiation and pathogenesis of retinoblastoma, (2) act as a transcriptional activator of the heme-oxygenase-1 gene, and (3) be a specific effector of estrogen action. Three transcript variants encoding different isoforms have been found for this gene.[2]

Contents

Interactions

PRDM2 has been shown to interact with Estrogen receptor alpha[3] and Retinoblastoma protein.[1]

References

  1. ^ a b Buyse IM, Shao G, Huang S (Jun 1995). "The retinoblastoma protein binds to RIZ, a zinc-finger protein that shares an epitope with the adenovirus E1A protein". Proc Natl Acad Sci U S A 92 (10): 4467–71. PMID 7538672.  
  2. ^ a b "Entrez Gene: PRDM2 PR domain containing 2, with ZNF domain". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7799.  
  3. ^ Abbondanza, C; Medici N, Nigro V, Rossi V, Gallo L, Piluso G, Belsito A, Roscigno A, Bontempo P, Puca A A, Molinari A M, Moncharmont B, Puca G A (Mar. 2000). "The retinoblastoma-interacting zinc-finger protein RIZ is a downstream effector of estrogen action". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 97 (7): 3130–5. doi:10.1073/pnas.050015697. ISSN 0027-8424. PMID 10706618.  

Further reading

  • Shapiro VS, Lee P, Winoto A (1995). "Identification and cloning of the G3B cDNA encoding a 3' segment of a protein binding to GATA-3.". Gene 163 (2): 329–30. doi:10.1016/0378-1119(95)00420-B. PMID 7590293.  
  • Muraosa Y, Takahashi K, Yoshizawa M, Shibahara S (1996). "cDNA cloning of a novel protein containing two zinc-finger domains that may function as a transcription factor for the human heme-oxygenase-1 gene.". Eur. J. Biochem. 235 (3): 471–9. doi:10.1111/j.1432-1033.1996.00471.x. PMID 8654390.  
  • Buyse IM, Takahashi EI, Huang S (1996). "Physical mapping of the retinoblastoma interacting zinc finger gene RIZ to D1S228 on chromosome 1p36.". Genomics 34 (1): 119–21. doi:10.1006/geno.1996.0249. PMID 8661032.  
  • Liu L, Shao G, Steele-Perkins G, Huang S (1997). "The retinoblastoma interacting zinc finger gene RIZ produces a PR domain-lacking product through an internal promoter.". J. Biol. Chem. 272 (5): 2984–91. doi:10.1074/jbc.272.5.2984. PMID 9006946.  
  • Xie M, Shao G, Buyse IM, Huang S (1997). "Transcriptional repression mediated by the PR domain zinc finger gene RIZ.". J. Biol. Chem. 272 (42): 26360–6. doi:10.1074/jbc.272.42.26360. PMID 9334209.  
  • He L, Yu JX, Liu L, et al. (1998). "RIZ1, but not the alternative RIZ2 product of the same gene, is underexpressed in breast cancer, and forced RIZ1 expression causes G2-M cell cycle arrest and/or apoptosis.". Cancer Res. 58 (19): 4238–44. PMID 9766644.  
  • Abbondanza C, Medici N, Nigro V, et al. (2000). "The retinoblastoma-interacting zinc-finger protein RIZ is a downstream effector of estrogen action.". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3130–5. doi:10.1073/pnas.050015697. PMID 10706618.  
  • Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. doi:10.1073/pnas.97.7.3491. PMID 10737800.  
  • Du Y, Carling T, Fang W, et al. (2001). "Hypermethylation in human cancers of the RIZ1 tumor suppressor gene, a member of a histone/protein methyltransferase superfamily.". Cancer Res. 61 (22): 8094–9. PMID 11719434.  
  • Sasaki O, Meguro K, Tohmiya Y, et al. (2003). "Nucleotide alteration of retinoblastoma protein-interacting zinc finger gene, RIZ, in human leukemia.". Tohoku J. Exp. Med. 196 (3): 193–201. doi:10.1620/tjem.196.193. PMID 12002276.  
  • Poetsch M, Dittberner T, Woenckhaus C (2002). "Frameshift mutations of RIZ, but no point mutations in RIZ1 exons in malignant melanomas with deletions in 1p36.". Oncogene 21 (19): 3038–42. doi:10.1038/sj.onc.1205457. PMID 12082534.  
  • Sasaki O, Meguro K, Tohmiya Y, et al. (2003). "Altered expression of retinoblastoma protein-interacting zinc finger gene, RIZ, in human leukaemia.". Br. J. Haematol. 119 (4): 940–8. doi:10.1046/j.1365-2141.2002.03972.x. PMID 12472571.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Tokumaru Y, Nomoto S, Jerónimo C, et al. (2003). "Biallelic inactivation of the RIZ1 gene in human gastric cancer.". Oncogene 22 (44): 6954–8. doi:10.1038/sj.onc.1206403. PMID 14534544.  
  • Kim KC, Geng L, Huang S (2004). "Inactivation of a histone methyltransferase by mutations in human cancers.". Cancer Res. 63 (22): 7619–23. PMID 14633678.  
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.  
  • Pan KF, Lu YY, Liu WG, et al. (2004). "Detection of frameshift mutations of RIZ in gastric cancers with microsatellite instability.". World J. Gastroenterol. 10 (18): 2719–22. PMID 15309726.  
  • Rossi M, Abbondanza C, D'Arcangelo A, et al. (2004). "The Zn-finger domain of RIZ protein promotes MCF-7 cell proliferation.". Cancer Lett. 215 (2): 229–37. doi:10.1016/j.canlet.2004.05.014. PMID 15488642.  
  • Grundberg E, Carling T, Brändström H, et al. (2005). "A deletion polymorphism in the RIZ gene, a female sex steroid hormone receptor coactivator, exhibits decreased response to estrogen in vitro and associates with low bone mineral density in young Swedish women.". J. Clin. Endocrinol. Metab. 89 (12): 6173–8. doi:10.1210/jc.2004-0403. PMID 15579774.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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