The Full Wiki

More info on PRKCB1

PRKCB1: Wikis


Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.


From Wikipedia, the free encyclopedia

Protein kinase C, beta 1

PDB rendering based on 1a25.
Available structures
1a25, 2i0e
Symbols PRKCB1; MGC41878; PKC-beta; PKCB; PRKCB; PRKCB2
External IDs OMIM176970 MGI97596 HomoloGene56424 GeneCards: PRKCB1 Gene
Species Human Mouse
Entrez 5579 18751
Ensembl ENSG00000166501 ENSMUSG00000052889
UniProt P05771 A0JNZ5
RefSeq (mRNA) NM_002738 NM_008855
RefSeq (protein) NP_002729 NP_032881
Location (UCSC) Chr 16:
23.75 - 24.14 Mb
Chr 7:
122.08 - 122.42 Mb
PubMed search [1] [2]

Protein kinase C beta type is an enzyme that in humans is encoded by the PRKCB gene.[1]

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase has been reported to be involved in many different cellular functions, such as B cell activation, apoptosis induction, endothelial cell proliferation, and intestinal sugar absorption. Studies in mice also suggest that this kinase may also regulate neuronal functions and correlate fear-induced conflict behavior after stress. Alternatively spliced transcript variants encoding distinct isoforms have been reported[2]. This gene could be associated with autism[3] [4].



PRKCB1 has been shown to interact with RIPK4,[5] Beta adrenergic receptor kinase,[6] PDLIM5[7] and GNB2L1.[8]


  1. ^ Kubo K, Ohno S, Suzuki K (Nov 1987). "Nucleotide sequence of the 3' portion of a human gene for protein kinase C beta I/beta II". Nucleic Acids Res 15 (17): 7179–80. PMID 3658678.  
  2. ^ "Entrez Gene: PRKCB1 protein kinase C, beta 1".  
  3. ^ Philippi, A; Roschmann, E; Tores, F; Lindenbaum, P (2005), "Haplotypes in the gene encoding protein kinase c-beta (PRKCB1) on chromosome 16 are associated with autism.", Mol. Psychiatry 10 (10): 950–604001704, 2005 Oct, doi:10.1038/, PMID :16027742,  
  4. ^ C Lintas, R Sacco, K Garbett, K Mirnics, R Militerni, C Bravaccio, P Curatolo, B Manzi, C Schneider, R Melmed, M Elia, T Pascucci, S Puglisi-Allegra, K-L Reichelt & A M Persico (2009). Involvement of the PRKCB1 gene in autistic disorder: significant genetic association and reduced neocortical gene expression. Mol Psychiatry, 14, [705-718].
  5. ^ Chen, L; Haider K, Ponda M, Cariappa A, Rowitch D, Pillai S (Jun. 2001). "Protein kinase C-associated kinase (PKK), a novel membrane-associated, ankyrin repeat-containing protein kinase". J. Biol. Chem. (United States) 276 (24): 21737–44. doi:10.1074/jbc.M008069200. ISSN 0021-9258. PMID 11278382.  
  6. ^ Yang, Xing-Long; Zhang Ya-Li, Lai Zhuo-Sheng, Xing Fei-Yue, Liu Yu-Hu (Apr. 2003). "Pleckstrin homology domain of G protein-coupled receptor kinase-2 binds to PKC and affects the activity of PKC kinase". World J. Gastroenterol. (China) 9 (4): 800–3. ISSN 1007-9327. PMID 12679936.  
  7. ^ Kuroda, S; Tokunaga C, Kiyohara Y, Higuchi O, Konishi H, Mizuno K, Gill G N, Kikkawa U (Dec. 1996). "Protein-protein interaction of zinc finger LIM domains with protein kinase C". J. Biol. Chem. (UNITED STATES) 271 (49): 31029–32. ISSN 0021-9258. PMID 8940095.  
  8. ^ Ron, D; Jiang Z, Yao L, Vagts A, Diamond I, Gordon A (Sep. 1999). "Coordinated movement of RACK1 with activated betaIIPKC". J. Biol. Chem. (UNITED STATES) 274 (38): 27039–46. ISSN 0021-9258. PMID 10480917.  

Further reading

  • Mochly-Rosen D (1995). "Localization of protein kinases by anchoring proteins: a theme in signal transduction.". Science 268 (5208): 247–51. doi:10.1126/science.7716516. PMID 7716516.  
  • Ali A, Hoeflich KP, Woodgett JR (2002). "Glycogen synthase kinase-3: properties, functions, and regulation.". Chem. Rev. 101 (8): 2527–40. doi:10.1021/cr000110o. PMID 11749387.  
  • Slater SJ, Ho C, Stubbs CD (2003). "The use of fluorescent phorbol esters in studies of protein kinase C-membrane interactions.". Chem. Phys. Lipids 116 (1-2): 75–91. doi:10.1016/S0009-3084(02)00021-X. PMID 12093536.  

See also



Got something to say? Make a comment.
Your name
Your email address