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Paired related homeobox 2
Identifiers
Symbols PRRX2; MGC19843; PMX2; PRX2
External IDs OMIM604675 MGI98218 HomoloGene7524 GeneCards: PRRX2 Gene
RNA expression pattern
PBB GE PRRX2 219729 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 51450 20204
Ensembl ENSG00000167157 ENSMUSG00000039476
UniProt Q99811 Q9CY80
RefSeq (mRNA) NM_016307 XM_979268
RefSeq (protein) NP_057391 XP_984362
Location (UCSC) Chr 9:
131.47 - 131.52 Mb
Chr 2:
30.67 - 30.7 Mb
PubMed search [1] [2]

Paired mesoderm homeobox protein 2 is a protein that in humans is encoded by the PRRX2 gene.[1][2]

The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins. Expression is localized to proliferating fetal fibroblasts and the developing dermal layer, with downregulated expression in adult skin. Increases in expression of this gene during fetal but not adult wound healing suggest a possible role in mechanisms that control mammalian dermal regeneration and prevent formation of scar response to wounding. The expression patterns provide evidence consistent with a role in fetal skin development and a possible role in cellular proliferation.[2]

References

  1. ^ Norris RA, Scott KK, Moore CS, Stetten G, Brown CR, Jabs EW, Wulfsberg EA, Yu J, Kern MJ (Mar 2001). "Human PRRX1 and PRRX2 genes: cloning, expression, genomic localization, and exclusion as disease genes for Nager syndrome". Mamm Genome 11 (11): 1000-5. PMID 11063257.  
  2. ^ a b "Entrez Gene: PRRX2 paired related homeobox 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51450.  

Further reading

  • Tokutomi Y, Araki N, Kataoka K, et al. (2007). "Oxidation of Prx2 and phosphorylation of GRP58 by angiotensin II in human coronary smooth muscle cells identified by 2D-DIGE analysis.". Biochem. Biophys. Res. Commun. 364 (4): 822–30. doi:10.1016/j.bbrc.2007.10.095. PMID 17964282.  
  • Wissmüller S, Kosian T, Wolf M, et al. (2006). "The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors.". Nucleic Acids Res. 34 (6): 1735–44. doi:10.1093/nar/gkl105. PMID 16582099.  
  • Gervais C, Mauvieux L, Perrusson N, et al. (2005). "A new translocation t(9;11)(q34;p15) fuses NUP98 to a novel homeobox partner gene, PRRX2, in a therapy-related acute myeloid leukemia.". Leukemia 19 (1): 145–8. doi:10.1038/sj.leu.2403565. PMID 15496970.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Scott KK, Norris RA, Potter SS, et al. (2003). "GeneChip microarrays facilitate identification of Protease Nexin-1 as a target gene of the Prx2 (S8) homeoprotein.". DNA Cell Biol. 22 (2): 95–105. doi:10.1089/104454903321515904. PMID 12713735.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Jones FS, McKean DM, Meech R, et al. (2002). "Regulation of vascular smooth muscle cell growth and adhesion by paired-related homeobox genes.". Chest 121 (3 Suppl): 89S–90S. doi:10.1378/chest.121.3_suppl.89S-a. PMID 11893718.  
  • Stelnicki EJ, Arbeit J, Cass DL, et al. (1998). "Modulation of the human homeobox genes PRX-2 and HOXB13 in scarless fetal wounds.". J. Invest. Dermatol. 111 (1): 57–63. doi:10.1046/j.1523-1747.1998.00238.x. PMID 9665387.  
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