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PVRL1: Wikis


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Poliovirus receptor-related 1 (herpesvirus entry mediator C; nectin)
Symbols PVRL1; PRR1; CD111; CLPED1; ED4; HIgR; HVEC; MGC142031; MGC16207; OFC7; PRR; PVRR; PVRR1; SK-12; nectin-1
External IDs OMIM600644 MGI1926483 HomoloGene2138 GeneCards: PVRL1 Gene
RNA expression pattern
PBB GE PVRL1 208455 at tn.png
PBB GE PVRL1 211846 s at tn.png
PBB GE PVRL1 211845 at tn.png
More reference expression data
Species Human Mouse
Entrez 5818 58235
Ensembl ENSG00000110400 n/a
UniProt Q15223 n/a
RefSeq (mRNA) NM_002855 NM_021424
RefSeq (protein) NP_002846 NP_067399
Location (UCSC) Chr 11:
119.01 - 119.1 Mb
PubMed search [1] [2]

Poliovirus receptor-related 1 (herpesvirus entry mediator C; nectin) and CD111 (Cluster of Differentiation 111), also known as PVRL1, is a human gene.[1]


See also


PVRL1 has been shown to interact with MLLT4.[2]


  1. ^ "Entrez Gene: PVRL1 poliovirus receptor-related 1 (herpesvirus entry mediator C; nectin)".  
  2. ^ Takahashi, K; Nakanishi H, Miyahara M, Mandai K, Satoh K, Satoh A, Nishioka H, Aoki J, Nomoto A, Mizoguchi A, Takai Y (May. 1999). "Nectin/PRR: an immunoglobulin-like cell adhesion molecule recruited to cadherin-based adherens junctions through interaction with Afadin, a PDZ domain-containing protein". J. Cell Biol. (UNITED STATES) 145 (3): 539–49. ISSN 0021-9525. PMID 10225955.  

Further reading

  • Bustos T, Simosa V, Pinto-Cisternas J, et al. (1992). "Autosomal recessive ectodermal dysplasia: I. An undescribed dysplasia/malformation syndrome.". Am. J. Med. Genet. 41 (4): 398–404. doi:10.1002/ajmg.1320410403. PMID 1776626.  
  • Lopez M, Eberlé F, Mattei MG, et al. (1995). "Complementary DNA characterization and chromosomal localization of a human gene related to the poliovirus receptor-encoding gene.". Gene 155 (2): 261–5. doi:10.1016/0378-1119(94)00842-G. PMID 7721102.  
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.  
  • Geraghty RJ, Krummenacher C, Cohen GH, et al. (1998). "Entry of alphaherpesviruses mediated by poliovirus receptor-related protein 1 and poliovirus receptor.". Science 280 (5369): 1618–20. doi:10.1126/science.280.5369.1618. PMID 9616127.  
  • Suzuki K, Bustos T, Spritz RA (1998). "Linkage disequilibrium mapping of the gene for Margarita Island ectodermal dysplasia (ED4) to 11q23.". Am. J. Hum. Genet. 63 (4): 1102–7. doi:10.1086/302072. PMID 9758630.  
  • Cocchi F, Menotti L, Mirandola P, et al. (1998). "The ectodomain of a novel member of the immunoglobulin subfamily related to the poliovirus receptor has the attributes of a bona fide receptor for herpes simplex virus types 1 and 2 in human cells.". J. Virol. 72 (12): 9992–10002. PMID 9811737.  
  • Cocchi F, Lopez M, Menotti L, et al. (1999). "The V domain of herpesvirus Ig-like receptor (HIgR) contains a major functional region in herpes simplex virus-1 entry into cells and interacts physically with the viral glycoprotein D.". Proc. Natl. Acad. Sci. U.S.A. 95 (26): 15700–5. doi:10.1073/pnas.95.26.15700. PMID 9861033.  
  • Takahashi K, Nakanishi H, Miyahara M, et al. (1999). "Nectin/PRR: an immunoglobulin-like cell adhesion molecule recruited to cadherin-based adherens junctions through interaction with Afadin, a PDZ domain-containing protein.". J. Cell Biol. 145 (3): 539–49. doi:10.1083/jcb.145.3.539. PMID 10225955.  
  • Miyahara M, Nakanishi H, Takahashi K, et al. (2000). "Interaction of nectin with afadin is necessary for its clustering at cell-cell contact sites but not for its cis dimerization or trans interaction.". J. Biol. Chem. 275 (1): 613–8. doi:10.1074/jbc.275.1.613. PMID 10617658.  
  • Suzuki K, Hu D, Bustos T, et al. (2000). "Mutations of PVRL1, encoding a cell-cell adhesion molecule/herpesvirus receptor, in cleft lip/palate-ectodermal dysplasia.". Nat. Genet. 25 (4): 427–30. doi:10.1038/78119. PMID 10932188.  
  • Lopez M, Cocchi F, Avitabile E, et al. (2001). "Novel, soluble isoform of the herpes simplex virus (HSV) receptor nectin1 (or PRR1-HIgR-HveC) modulates positively and negatively susceptibility to HSV infection.". J. Virol. 75 (12): 5684–91. doi:10.1128/JVI.75.12.5684-5691.2001. PMID 11356977.  
  • Sözen MA, Suzuki K, Tolarova MM, et al. (2001). "Mutation of PVRL1 is associated with sporadic, non-syndromic cleft lip/palate in northern Venezuela.". Nat. Genet. 29 (2): 141–2. doi:10.1038/ng740. PMID 11559849.  
  • Struyf F, Posavad CM, Keyaerts E, et al. (2002). "Search for polymorphisms in the genes for herpesvirus entry mediator, nectin-1, and nectin-2 in immune seronegative individuals.". J. Infect. Dis. 185 (1): 36–44. doi:10.1086/338116. PMID 11756979.  
  • Fabre S, Reymond N, Cocchi F, et al. (2002). "Prominent role of the Ig-like V domain in trans-interactions of nectins. Nectin3 and nectin 4 bind to the predicted C-C'-C"-D beta-strands of the nectin1 V domain.". J. Biol. Chem. 277 (30): 27006–13. doi:10.1074/jbc.M203228200. PMID 12011057.  
  • Yoon M, Spear PG (2002). "Disruption of adherens junctions liberates nectin-1 to serve as receptor for herpes simplex virus and pseudorabies virus entry.". J. Virol. 76 (14): 7203–8. doi:10.1128/JVI.76.14.7203-7208.2002. PMID 12072519.  
  • Struyf F, Martinez WM, Spear PG (2002). "Mutations in the N-terminal domains of nectin-1 and nectin-2 reveal differences in requirements for entry of various alphaherpesviruses and for nectin-nectin interactions.". J. Virol. 76 (24): 12940–50. doi:10.1128/JVI.76.24.12940-12950.2002. PMID 12438620.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Takekuni K, Ikeda W, Fujito T, et al. (2003). "Direct binding of cell polarity protein PAR-3 to cell-cell adhesion molecule nectin at neuroepithelial cells of developing mouse.". J. Biol. Chem. 278 (8): 5497–500. doi:10.1074/jbc.C200707200. PMID 12515806.  
  • Krummenacher C, Baribaud I, Eisenberg RJ, Cohen GH (2003). "Cellular localization of nectin-1 and glycoprotein D during herpes simplex virus infection.". J. Virol. 77 (16): 8985–99. doi:10.1128/JVI.77.16.8985-8999.2003. PMID 12885915.  
  • Bender FC, Whitbeck JC, Ponce de Leon M, et al. (2003). "Specific association of glycoprotein B with lipid rafts during herpes simplex virus entry.". J. Virol. 77 (17): 9542–52. doi:10.1128/JVI.77.17.9542-9552.2003. PMID 12915568.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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