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Poliovirus receptor-related 3
Identifiers
Symbols PVRL3; CDw113; DKFZP566B0846; FLJ90624; PPR3; PRR3; PVRR3; nectin-3
External IDs OMIM607147 HomoloGene9162 GeneCards: PVRL3 Gene
RNA expression pattern
PBB GE PVRL3 213325 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 25945 n/a
Ensembl ENSG00000177707 n/a
UniProt Q9NQS3 n/a
RefSeq (mRNA) NM_015480 n/a
RefSeq (protein) NP_056295 n/a
Location (UCSC) Chr 3:
112.27 - 112.4 Mb
n/a
PubMed search [1] n/a

Poliovirus receptor-related 3, also known as PVRL3 and CD113 (Cluster of Differentiation 113), is a human gene.[1]

Nectins (e.g., PVRL1; MIM 600644) are immunoglobulin-like adhesion molecules that interact with afadin (AF6; MIM 159559). Afadin is an actin filament-binding protein that connects nectins to the actin cytoskeleton. The nectin-afadin system organizes adherens junctions cooperatively with the cadherin (see MIM 192090)-catenin (see MIM 116805) system in epithelial cells.[supplied by OMIM][1]

Contents

See also

Interactions

PVRL3 has been shown to interact with MLLT4[2][3] and PARD3.[4]

References

  1. ^ a b "Entrez Gene: PVRL3 poliovirus receptor-related 3". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=25945.  
  2. ^ Satoh-Horikawa, K; Nakanishi H, Takahashi K, Miyahara M, Nishimura M, Tachibana K, Mizoguchi A, Takai Y (Apr. 2000). "Nectin-3, a new member of immunoglobulin-like cell adhesion molecules that shows homophilic and heterophilic cell-cell adhesion activities". J. Biol. Chem. (UNITED STATES) 275 (14): 10291–9. ISSN 0021-9258. PMID 10744716.  
  3. ^ Reymond, N; Borg J P, Lecocq E, Adelaide J, Campadelli-Fiume G, Dubreuil P, Lopez M (Sep. 2000). "Human nectin3/PRR3: a novel member of the PVR/PRR/nectin family that interacts with afadin". Gene (NETHERLANDS) 255 (2): 347–55. ISSN 0378-1119. PMID 11024295.  
  4. ^ Takekuni, Kyoji; Ikeda Wataru, Fujito Tsutomu, Morimoto Koji, Takeuchi Masakazu, Monden Morito, Takai Yoshimi (Feb. 2003). "Direct binding of cell polarity protein PAR-3 to cell-cell adhesion molecule nectin at neuroepithelial cells of developing mouse". J. Biol. Chem. (United States) 278 (8): 5497–500. doi:10.1074/jbc.C200707200. ISSN 0021-9258. PMID 12515806.  

Further reading

  • Satoh-Horikawa K, Nakanishi H, Takahashi K, et al. (2000). "Nectin-3, a new member of immunoglobulin-like cell adhesion molecules that shows homophilic and heterophilic cell-cell adhesion activities.". J. Biol. Chem. 275 (14): 10291–9. doi:10.1074/jbc.275.14.10291. PMID 10744716.  
  • Reymond N, Borg JP, Lecocq E, et al. (2000). "Human nectin3/PRR3: a novel member of the PVR/PRR/nectin family that interacts with afadin.". Gene 255 (2): 347–55. doi:10.1016/S0378-1119(00)00316-4. PMID 11024295.  
  • Fabre S, Reymond N, Cocchi F, et al. (2002). "Prominent role of the Ig-like V domain in trans-interactions of nectins. Nectin3 and nectin 4 bind to the predicted C-C'-C"-D beta-strands of the nectin1 V domain.". J. Biol. Chem. 277 (30): 27006–13. doi:10.1074/jbc.M203228200. PMID 12011057.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Takekuni K, Ikeda W, Fujito T, et al. (2003). "Direct binding of cell polarity protein PAR-3 to cell-cell adhesion molecule nectin at neuroepithelial cells of developing mouse.". J. Biol. Chem. 278 (8): 5497–500. doi:10.1074/jbc.C200707200. PMID 12515806.  
  • Mueller S, Wimmer E (2003). "Recruitment of nectin-3 to cell-cell junctions through trans-heterophilic interaction with CD155, a vitronectin and poliovirus receptor that localizes to alpha(v)beta3 integrin-containing membrane microdomains.". J. Biol. Chem. 278 (33): 31251–60. doi:10.1074/jbc.M304166200. PMID 12759359.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.  
  • Fujito T, Ikeda W, Kakunaga S, et al. (2005). "Inhibition of cell movement and proliferation by cell-cell contact-induced interaction of Necl-5 with nectin-3.". J. Cell Biol. 171 (1): 165–73. doi:10.1083/jcb.200501090. PMID 16216929.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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