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Palmitoylethanolamide
Palmitoylethanolamide.png
IUPAC name
Other names Palmidrol; N-Palmitoylethanolamine; Palmitamide MEA; Palmitylethanolamide; Hydroxyethylpalmitamide
Identifiers
CAS number 544-31-0
PubChem 4671
SMILES
Properties
Molecular formula C18H37NO2
Molar mass 299.49
Appearance White solid
Melting point

59-60 °C

Solubility in other solvents soluble in ethanol and DMSO
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Palmitoylethanolamide (PEA) is an endogenous fatty acid amide which has been demonstrated to bind to peroxisome proliferator-activated receptor alpha (PPAR-α)[1][2], GPR55 and GPR119.[3] PEA has been shown to have anti-inflammatory[2] and anti-nociceptive properties. [4]

PEA is metabolized by fatty acid amide hydrolase (FAAH) and N-acylethanolamine-hydrolyzing acid amidase (NAAA), the latter of which has more specificity towards PEA over other fatty acid amides.[5]

See also

References

  1. ^ O'Sullivan (2007). "Cannabinoids go nuclear: evidence for activation of peroxisome proliferator-activated receptors". British journal of pharmacology 152 (5): 576–582. doi:10.1038/sj.bjp.0707423. PMID 17704824.   edit
  2. ^ a b Lo Verme, J.; Fu, J.; Astarita, G.; La Rana, G.; Russo, R.; Calignano, A.; Piomelli, D. (2005). "The nuclear receptor peroxisome proliferator-activated receptor-alpha mediates the anti-inflammatory actions of palmitoylethanolamide". Molecular pharmacology 67 (1): 15–19. doi:10.1124/mol.104.006353. PMID 15465922.   edit
  3. ^ Godlewski, G.; Offertáler, L.; Wagner, J. A.; Kunos, G. (2009). "Receptors for acylethanolamides—GPR55 and GPR119". Prostaglandins & Other Lipid Mediators 89: 105–297. doi:10.1016/j.prostaglandins.2009.07.001. PMID 19615459.   edit
  4. ^ Calignano A, La Rana G, Piomelli D (2001). "Antinociceptive activity of the endogenous fatty acid amide, palmitylethanolamide". Eur J Pharmacol. 419 (2-3): 191–8. doi:10.1016/S0014-2999(01)00988-8. PMID 11426841.   edit
  5. ^ Tsuboi, K.; Takezaki, N.; Ueda, N. (2007). "The N-Acylethanolamine-Hydrolyzing Acid Amidase (NAAA)". Chemistry & Biodiversity 4: 1914. doi:10.1002/cbdv.200790159. PMID 17712833.   edit
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