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Palmoplantar keratoderma
Classification and external resources

A picture of a 40 y/o Caucasian female with only the soles of the feet affected. The amputation was prior to this admission
ICD-10 L85.1-L85.2
ICD-9 701.1, 757.39
OMIM 144200 600962
DiseasesDB 32042
eMedicine derm/589
MeSH D007645

Palmoplantar keratodermas are a heterogeneous group of disorders characterized by abnormal thickening of the palms and soles, with autosomal recessive and dominant, X-linked, and acquired forms all having been described.[1]:505[2]:211


Clinical patterns

Clinically, three distinct patterns of palmoplantar keratoderma may be identified[1]:505:


Epidermolytic palmoplantar keratoderma has been associated with keratin 9 and keratin 16.[3]

Nonepidermolytic palmoplantar keratoderma has been associated with keratin 1 and keratin 16.[4]

See also


  1. ^ a b Freedberg, et al. (2003). Fitzpatrick's Dermatology in General Medicine. (6th ed.). McGraw-Hill. ISBN 0071380760.
  2. ^ James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology. (10th ed.). Saunders. ISBN 0721629210.
  3. ^ Online 'Mendelian Inheritance in Man' (OMIM) 144200
  4. ^ Online 'Mendelian Inheritance in Man' (OMIM) 600962


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