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Pancreatic polypeptide: Wikis


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pancreatic polypeptide
IHC for Pancreatic Polypeptide in a mouse pancreas, 200x.
Symbol PPY
Entrez 5539
HUGO 9327
OMIM 167780
RefSeq NM_002722
UniProt P01298
Other data
Locus Chr. 17 p11.1-qter

Pancreatic polypeptide is a polypeptide secreted by PP cells in the endocrine pancreas predominantly in the head of the pancreas. It consists of 36 amino acids and has molecular weight about 4200 Da.

The function of PP is to self regulate the pancreas secretion activities (endocrine and exocrine), it also has effects on hepatic glycogen levels and gastrointestinal secretions.

Its secretion in humans is increased after a protein meal, fasting, exercise, and acute hypoglycemia and is decreased by somatostatin and intravenous glucose.


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