The Full Wiki

More info on Pancreatic polypeptide receptor 1

Pancreatic polypeptide receptor 1: Wikis

Advertisements
  

Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.

Encyclopedia

From Wikipedia, the free encyclopedia

edit
Pancreatic polypeptide receptor 1
Identifiers
Symbols PPYR1; PP1; MGC116897; NPY4-R; NPY4R; Y4
External IDs OMIM601790 MGI105374 HomoloGene38119 IUPHAR: Y4 GeneCards: PPYR1 Gene
RNA expression pattern
PBB GE PPYR1 210956 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5540 19065
Ensembl ENSG00000204174 ENSMUSG00000048337
UniProt P50391 Q3UN46
RefSeq (mRNA) XM_001129329 NM_008919
RefSeq (protein) XP_001129329 NP_032945
Location (UCSC) Chr 10:
46.5 - 46.51 Mb
Chr 14:
32.97 - 32.98 Mb
PubMed search [1] [2]

Neuropeptide Y receptor type 4 is a protein that in humans is encoded by the PPYR1 gene.[1][2]

Contents

Selective Ligands

Advertisements

Agonists

Antagonists

See also

References

  1. ^ Lutz CM, Richards JE, Scott KL, Sinha S, Yang-Feng TL, Frankel WN, Thompson DA (Feb 1998). "Neuropeptide Y receptor genes mapped in human and mouse: receptors with high affinity for pancreatic polypeptide are not clustered with receptors specific for neuropeptide Y and peptide YY". Genomics 46 (2): 287-90. doi:10.1006/geno.1997.5024. PMID 9417917.  
  2. ^ "Entrez Gene: PPYR1 pancreatic polypeptide receptor 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5540.  
  3. ^ Ziemek R, Schneider E, Kraus A, Cabrele C, Beck-Sickinger AG, Bernhardt G, Buschauer A (2007). "Determination of affinity and activity of ligands at the human neuropeptide Y Y4 receptor by flow cytometry and aequorin luminescence". Journal of Receptor and Signal Transduction Research 27 (4): 217–33. doi:10.1080/10799890701505206. PMID 17885919.  

External links

Further reading

  • Keire DA, Bowers CW, Solomon TE, Reeve JR (2002). "Structure and receptor binding of PYY analogs.". Peptides 23 (2): 305–21. doi:10.1016/S0196-9781(01)00602-7. PMID 11825645.  
  • Balasubramaniam A (2002). "Clinical potentials of neuropeptide Y family of hormones.". Am. J. Surg. 183 (4): 430–4. doi:10.1016/S0002-9610(02)00803-6. PMID 11975932.  
  • Parker E, Van Heek M, Stamford A (2002). "Neuropeptide Y receptors as targets for anti-obesity drug development: perspective and current status.". Eur. J. Pharmacol. 440 (2-3): 173–87. doi:10.1016/S0014-2999(02)01427-9. PMID 12007534.  
  • Benaim G, Villalobo A (2002). "Phosphorylation of calmodulin. Functional implications.". Eur. J. Biochem. 269 (15): 3619–31. doi:10.1046/j.1432-1033.2002.03038.x. PMID 12153558.  
  • Lundell I, Blomqvist AG, Berglund MM, et al. (1996). "Cloning of a human receptor of the NPY receptor family with high affinity for pancreatic polypeptide and peptide YY.". J. Biol. Chem. 270 (49): 29123–8. doi:10.1074/jbc.270.49.29123. PMID 7493937.  
  • Bard JA, Walker MW, Branchek TA, Weinshank RL (1995). "Cloning and functional expression of a human Y4 subtype receptor for pancreatic polypeptide, neuropeptide Y, and peptide YY.". J. Biol. Chem. 270 (45): 26762–5. doi:10.1074/jbc.270.45.26762. PMID 7592911.  
  • Yan H, Yang J, Marasco J, et al. (1996). "Cloning and functional expression of cDNAs encoding human and rat pancreatic polypeptide receptors.". Proc. Natl. Acad. Sci. U.S.A. 93 (10): 4661–5. doi:10.1073/pnas.93.10.4661. PMID 8643460.  
  • Kawabe T, Muslin AJ, Korsmeyer SJ (1997). "HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpoint.". Nature 385 (6615): 454–8. doi:10.1038/385454a0. PMID 9009195.  
  • Darby K, Eyre HJ, Lapsys N, et al. (1998). "Assignment of the Y4 receptor gene (PPYR1) to human chromosome 10q11.2 and mouse chromosome 14.". Genomics 46 (3): 513–5. doi:10.1006/geno.1997.5071. PMID 9441761.  
  • Hsieh-Wilson LC, Allen PB, Watanabe T, et al. (1999). "Characterization of the neuronal targeting protein spinophilin and its interactions with protein phosphatase-1.". Biochemistry 38 (14): 4365–73. doi:10.1021/bi982900m. PMID 10194355.  
  • Smith FD, Oxford GS, Milgram SL (1999). "Association of the D2 dopamine receptor third cytoplasmic loop with spinophilin, a protein phosphatase-1-interacting protein.". J. Biol. Chem. 274 (28): 19894–900. doi:10.1074/jbc.274.28.19894. PMID 10391935.  
  • Marx SO, Reiken S, Hisamatsu Y, et al. (2000). "PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts.". Cell 101 (4): 365–76. doi:10.1016/S0092-8674(00)80847-8. PMID 10830164.  
  • Connor JH, Weiser DC, Li S, et al. (2001). "Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1.". Mol. Cell. Biol. 21 (20): 6841–50. doi:10.1128/MCB.21.20.6841-6850.2001. PMID 11564868.  
  • Cavadas C, Silva AP, Mosimann F, et al. (2001). "NPY regulates catecholamine secretion from human adrenal chromaffin cells.". J. Clin. Endocrinol. Metab. 86 (12): 5956–63. doi:10.1210/jc.86.12.5956. PMID 11739470.  
  • Cox HM, Tough IR (2002). "Neuropeptide Y, Y1, Y2 and Y4 receptors mediate Y agonist responses in isolated human colon mucosa.". Br. J. Pharmacol. 135 (6): 1505–12. doi:10.1038/sj.bjp.0704604. PMID 11906964.  
  • Wu DY, Tkachuck DC, Roberson RS, Schubach WH (2002). "The human SNF5/INI1 protein facilitates the function of the growth arrest and DNA damage-inducible protein (GADD34) and modulates GADD34-bound protein phosphatase-1 activity.". J. Biol. Chem. 277 (31): 27706–15. doi:10.1074/jbc.M200955200. PMID 12016208.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


Advertisements






Got something to say? Make a comment.
Your name
Your email address
Message