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Pancreatic polypeptide receptor 1
Symbols PPYR1; PP1; MGC116897; NPY4-R; NPY4R; Y4
External IDs OMIM601790 MGI105374 HomoloGene38119 IUPHAR: Y4 GeneCards: PPYR1 Gene
RNA expression pattern
PBB GE PPYR1 210956 at tn.png
More reference expression data
Species Human Mouse
Entrez 5540 19065
Ensembl ENSG00000204174 ENSMUSG00000048337
UniProt P50391 Q3UN46
RefSeq (mRNA) XM_001129329 NM_008919
RefSeq (protein) XP_001129329 NP_032945
Location (UCSC) Chr 10:
46.5 - 46.51 Mb
Chr 14:
32.97 - 32.98 Mb
PubMed search [1] [2]

Neuropeptide Y receptor type 4 is a protein that in humans is encoded by the PPYR1 gene.[1][2]


Selective Ligands




See also


  1. ^ Lutz CM, Richards JE, Scott KL, Sinha S, Yang-Feng TL, Frankel WN, Thompson DA (Feb 1998). "Neuropeptide Y receptor genes mapped in human and mouse: receptors with high affinity for pancreatic polypeptide are not clustered with receptors specific for neuropeptide Y and peptide YY". Genomics 46 (2): 287-90. doi:10.1006/geno.1997.5024. PMID 9417917.  
  2. ^ "Entrez Gene: PPYR1 pancreatic polypeptide receptor 1".  
  3. ^ Ziemek R, Schneider E, Kraus A, Cabrele C, Beck-Sickinger AG, Bernhardt G, Buschauer A (2007). "Determination of affinity and activity of ligands at the human neuropeptide Y Y4 receptor by flow cytometry and aequorin luminescence". Journal of Receptor and Signal Transduction Research 27 (4): 217–33. doi:10.1080/10799890701505206. PMID 17885919.  

External links

Further reading

  • Keire DA, Bowers CW, Solomon TE, Reeve JR (2002). "Structure and receptor binding of PYY analogs.". Peptides 23 (2): 305–21. doi:10.1016/S0196-9781(01)00602-7. PMID 11825645.  
  • Balasubramaniam A (2002). "Clinical potentials of neuropeptide Y family of hormones.". Am. J. Surg. 183 (4): 430–4. doi:10.1016/S0002-9610(02)00803-6. PMID 11975932.  
  • Parker E, Van Heek M, Stamford A (2002). "Neuropeptide Y receptors as targets for anti-obesity drug development: perspective and current status.". Eur. J. Pharmacol. 440 (2-3): 173–87. doi:10.1016/S0014-2999(02)01427-9. PMID 12007534.  
  • Benaim G, Villalobo A (2002). "Phosphorylation of calmodulin. Functional implications.". Eur. J. Biochem. 269 (15): 3619–31. doi:10.1046/j.1432-1033.2002.03038.x. PMID 12153558.  
  • Lundell I, Blomqvist AG, Berglund MM, et al. (1996). "Cloning of a human receptor of the NPY receptor family with high affinity for pancreatic polypeptide and peptide YY.". J. Biol. Chem. 270 (49): 29123–8. doi:10.1074/jbc.270.49.29123. PMID 7493937.  
  • Bard JA, Walker MW, Branchek TA, Weinshank RL (1995). "Cloning and functional expression of a human Y4 subtype receptor for pancreatic polypeptide, neuropeptide Y, and peptide YY.". J. Biol. Chem. 270 (45): 26762–5. doi:10.1074/jbc.270.45.26762. PMID 7592911.  
  • Yan H, Yang J, Marasco J, et al. (1996). "Cloning and functional expression of cDNAs encoding human and rat pancreatic polypeptide receptors.". Proc. Natl. Acad. Sci. U.S.A. 93 (10): 4661–5. doi:10.1073/pnas.93.10.4661. PMID 8643460.  
  • Kawabe T, Muslin AJ, Korsmeyer SJ (1997). "HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpoint.". Nature 385 (6615): 454–8. doi:10.1038/385454a0. PMID 9009195.  
  • Darby K, Eyre HJ, Lapsys N, et al. (1998). "Assignment of the Y4 receptor gene (PPYR1) to human chromosome 10q11.2 and mouse chromosome 14.". Genomics 46 (3): 513–5. doi:10.1006/geno.1997.5071. PMID 9441761.  
  • Hsieh-Wilson LC, Allen PB, Watanabe T, et al. (1999). "Characterization of the neuronal targeting protein spinophilin and its interactions with protein phosphatase-1.". Biochemistry 38 (14): 4365–73. doi:10.1021/bi982900m. PMID 10194355.  
  • Smith FD, Oxford GS, Milgram SL (1999). "Association of the D2 dopamine receptor third cytoplasmic loop with spinophilin, a protein phosphatase-1-interacting protein.". J. Biol. Chem. 274 (28): 19894–900. doi:10.1074/jbc.274.28.19894. PMID 10391935.  
  • Marx SO, Reiken S, Hisamatsu Y, et al. (2000). "PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts.". Cell 101 (4): 365–76. doi:10.1016/S0092-8674(00)80847-8. PMID 10830164.  
  • Connor JH, Weiser DC, Li S, et al. (2001). "Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1.". Mol. Cell. Biol. 21 (20): 6841–50. doi:10.1128/MCB.21.20.6841-6850.2001. PMID 11564868.  
  • Cavadas C, Silva AP, Mosimann F, et al. (2001). "NPY regulates catecholamine secretion from human adrenal chromaffin cells.". J. Clin. Endocrinol. Metab. 86 (12): 5956–63. doi:10.1210/jc.86.12.5956. PMID 11739470.  
  • Cox HM, Tough IR (2002). "Neuropeptide Y, Y1, Y2 and Y4 receptors mediate Y agonist responses in isolated human colon mucosa.". Br. J. Pharmacol. 135 (6): 1505–12. doi:10.1038/sj.bjp.0704604. PMID 11906964.  
  • Wu DY, Tkachuck DC, Roberson RS, Schubach WH (2002). "The human SNF5/INI1 protein facilitates the function of the growth arrest and DNA damage-inducible protein (GADD34) and modulates GADD34-bound protein phosphatase-1 activity.". J. Biol. Chem. 277 (31): 27706–15. doi:10.1074/jbc.M200955200. PMID 12016208.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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