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Pangamic acid
Pangamic acid.png
IUPAC name
Other names Vitamin B15; Gluconodimethylaminoacetic acid
CAS number 20858-86-0
Molecular formula C10H19NO8
Molar mass 281.26 g/mol
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Pangamic acid is an ester derived from gluconic acid and dimethylglycine.[1] It was first isolated by Ernst T. Krebs from apricot kernels,[2] and has since been identified in some foods such as pulses[3] and rice bran.

Pangamic acid was also promoted by Krebs as vitamin B15, but it is not accepted as a vitamin because it has not been shown to be essential in the human diet, and a deficiency in consumption of pangamic acid is not known to be associated with any disease.[4]

The calcium salt of pangamic acid, calcium pangamate, is used as a mineral supplement. Like thiamine, pangamic acid causes a temporary drop in blood pressure lasting for about 20 minutes.


  1. ^ Recent data on the structure of pangamic acid (vitamin B15). Telegdy Kovats, Laszlo; Berndorfer-Kraszner, Eva; Juhasz, Agnes; Gabor, Tamas. Acta Alimentaria Academiae Scientiarum Hungaricae (1976), 5(3), 281-8.
  2. ^ KREBS E T Sr; KREBS E T Jr; BEARD H H; MALIN R; HARRIS A T; BARTLETT C L Pangamic acid sodium: a newly isolated crystalline water-soluble factor; a preliminary report. International record of medicine and general practice clinics (1951), 164(1), 18-23.
  3. ^ Singh, Jagdev; Handa, Mrs. Geeta; Nandi, L. N.; Manavalan, R.; Atal, C. K. D-Gluconodimethylaminoacetic acid from natural sources. Indian Drugs (1983), 20(5), 185-9.
  4. ^ "Vitamin B15 - Pangamic Acid", Elson M. Haas M.D.


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