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Panniculitis: Wikis


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Classification and external resources
ICD-10 M79.3
ICD-9 729.3
DiseasesDB 29081
MeSH D015434

Panniculitis is a group of diseases whose hallmark is inflammation of subcutaneous adipose tissue (the fatty layer under the skin).[1] Symptoms include tender skin nodules, and systemic signs such as weight loss and fatigue.

Restated, an inflammatory disorder primarily localized in the subcutaneous fat is termed a "panniculitis," a group of disorders that may be challenging both for the clinician and the dermatopathologist.[2]:487





It can occur in any fatty tissue (cutaneous or visceral) and is often diagnosed on the basis of a deep skin biopsy, and can be further classified by histological characteristics based on the location of the inflammatory cells (within fatty lobules or in the septa which separate them) and on the presence or absence of vasculitis.

There are thus four main histological subtypes:

  1. lobular panniculitis without vasculitis (acute panniculitis, previously termed Weber-Christian disease, [3] systemic nodular panniculitis)
  2. lobular panniculitis with vasculitis
  3. septal panniculitis without vasculitis
  4. septal panniculitis with vasculitis


Panniculitis can also be classified based on the presence or absence of systemic symptoms:

Associated conditions

Lipoatrophy or lipodystrophy (the loss of subcutaneous adipose tissue) can occur in any of these conditions.

See also


  1. ^ panniculitis at Dorland's Medical Dictionary
  2. ^ James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0.  
  3. ^ "eMedicine - Weber-Christian Disease : Article by Moise L Levy". Retrieved 2008-03-25.  
  4. ^ "eMedicine - Cold Panniculitis : Article by Geromanta Baleviciene". Retrieved 2008-03-25.  

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