Parathyroid hormone receptor 1: Wikis


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Parathyroid hormone receptor 1
Symbols PTHR1; PTHR; MGC138426; MGC138452
External IDs OMIM168468 MGI97801 HomoloGene267 IUPHAR: GeneCards: PTHR1 Gene
RNA expression pattern
PBB GE PTHR1 205911 at tn.png
More reference expression data
Species Human Mouse
Entrez 5745 19228
Ensembl ENSG00000160801 ENSMUSG00000032492
UniProt Q03431 Q80WU8
RefSeq (mRNA) NM_000316 NM_011199
RefSeq (protein) NP_000307 NP_035329
Location (UCSC) Chr 3:
46.9 - 46.93 Mb
Chr 9:
110.57 - 110.59 Mb
PubMed search [1] [2]

Parathyroid hormone receptor 1 also known as PTHR1 is a protein which in humans is encoded by the PTHR1 gene. PTHR1 functions as a receptor for parathyroid hormone (PTH) and for parathyroid hormone-like hormone (PTHLH).



This "classical" PTH receptor is expressed in high levels in bone and kidney and regulates calcium ion homeostasis through activation of adenylate cyclase and phospholipase C.[1][2] In bone, it is expressed on the surface of osteoblasts. When the receptor is activated, these cells in turn stimulate osteoclasts to ultimately increase the resorption rate.


It is a member of the secretin family of G protein-coupled receptors. The activity of this receptor is mediated by Gs G proteins which activate adenylyl cyclase. Besides, they also activate phosphatidylinositol-calcium second messenger system.


Defects in this receptor are known to be the cause of Jansen's metaphyseal chondrodysplasia (JMC), chondrodysplasia Blomstrand type (BOCD), as well as enchondromatosis.[3]


Parathyroid hormone receptor 1 has been shown to interact with Sodium-hydrogen exchange regulatory cofactor 2[4] and Sodium-hydrogen antiporter 3 regulator 1.[4]

See also


  1. ^ Mannstadt M, Jüppner H, Gardella TJ (1999). "Receptors for PTH and PTHrP: their biological importance and functional properties". Am. J. Physiol. 277 (5 Pt 2): F665–75. PMID 10564229.  
  2. ^ Offermanns S, Iida-Klein A, Segre GV, Simon MI (1996). "G alpha q family members couple parathyroid hormone (PTH)/PTH-related peptide and calcitonin receptors to phospholipase C in COS-7 cells". Mol. Endocrinol. 10 (5): 566–74. doi:10.1210/me.10.5.566. PMID 8732687.  
  3. ^ "Entrez Gene: PTHR1 parathyroid hormone receptor 1".  
  4. ^ a b Mahon, Matthew J; Donowitz Mark, Yun C Chris, Segre Gino V (Jun. 2002). "Na(+)/H(+ ) exchanger regulatory factor 2 directs parathyroid hormone 1 receptor signalling". Nature (England) 417 (6891): 858–61. doi:10.1038/nature00816. ISSN 0028-0836. PMID 12075354.  

Further reading

  • Bonaventure J, Silve C (2006). "[Hereditary skeletal dysplasias and FGFR3 and PTHR1 signaling pathways]". Med Sci (Paris) 21 (11): 954–61. PMID 16274647.  
  • Dawson SJ, White LA (1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin.". J. Infect. 24 (3): 317–20. doi:10.1016/S0163-4453(05)80037-4. PMID 1602151.  
  • Schipani E, Kruse K, Jüppner H (1995). "A constitutively active mutant PTH-PTHrP receptor in Jansen-type metaphyseal chondrodysplasia.". Science 268 (5207): 98–100. doi:10.1126/science.7701349. PMID 7701349.  
  • Schipani E, Weinstein LS, Bergwitz C, et al. (1995). "Pseudohypoparathyroidism type Ib is not caused by mutations in the coding exons of the human parathyroid hormone (PTH)/PTH-related peptide receptor gene.". J. Clin. Endocrinol. Metab. 80 (5): 1611–21. doi:10.1210/jc.80.5.1611. PMID 7745008.  
  • Pausova Z, Bourdon J, Clayton D, et al. (1994). "Cloning of a parathyroid hormone/parathyroid hormone-related peptide receptor (PTHR) cDNA from a rat osteosarcoma (UMR 106) cell line: chromosomal assignment of the gene in the human, mouse, and rat genomes.". Genomics 20 (1): 20–6. doi:10.1006/geno.1994.1122. PMID 8020952.  
  • McCuaig KA, Clarke JC, White JH (1994). "Molecular cloning of the gene encoding the mouse parathyroid hormone/parathyroid hormone-related peptide receptor.". Proc. Natl. Acad. Sci. U.S.A. 91 (11): 5051–5. doi:10.1073/pnas.91.11.5051. PMID 8197183.  
  • Schipani E, Karga H, Karaplis AC, et al. (1993). "Identical complementary deoxyribonucleic acids encode a human renal and bone parathyroid hormone (PTH)/PTH-related peptide receptor.". Endocrinology 132 (5): 2157–65. doi:10.1210/en.132.5.2157. PMID 8386612.  
  • Schneider H, Feyen JH, Seuwen K, Movva NR (1993). "Cloning and functional expression of a human parathyroid hormone receptor.". Eur. J. Pharmacol. 246 (2): 149–55. doi:10.1016/0922-4106(93)90092-N. PMID 8397094.  
  • Schipani E, Langman CB, Parfitt AM, et al. (1996). "Constitutively activated receptors for parathyroid hormone and parathyroid hormone-related peptide in Jansen's metaphyseal chondrodysplasia.". N. Engl. J. Med. 335 (10): 708–14. doi:10.1056/NEJM199609053351004. PMID 8703170.  
  • Zhou AT, Bessalle R, Bisello A, et al. (1997). "Direct mapping of an agonist-binding domain within the parathyroid hormone/parathyroid hormone-related protein receptor by photoaffinity crosslinking.". Proc. Natl. Acad. Sci. U.S.A. 94 (8): 3644–9. doi:10.1073/pnas.94.8.3644. PMID 9108031.  
  • Schipani E, Jensen GS, Pincus J, et al. (1997). "Constitutive activation of the cyclic adenosine 3',5'-monophosphate signaling pathway by parathyroid hormone (PTH)/PTH-related peptide receptors mutated at the two loci for Jansen's metaphyseal chondrodysplasia.". Mol. Endocrinol. 11 (7): 851–8. doi:10.1210/me.11.7.851. PMID 9178745.  
  • Jobert AS, Zhang P, Couvineau A, et al. (1998). "Absence of functional receptors for parathyroid hormone and parathyroid hormone-related peptide in Blomstrand chondrodysplasia.". J. Clin. Invest. 102 (1): 34–40. doi:10.1172/JCI2918. PMID 9649554.  
  • Pellegrini M, Bisello A, Rosenblatt M, et al. (1998). "Binding domain of human parathyroid hormone receptor: from conformation to function.". Biochemistry 37 (37): 12737–43. doi:10.1021/bi981265h. PMID 9737850.  
  • Zhang P, Jobert AS, Couvineau A, Silve C (1998). "A homozygous inactivating mutation in the parathyroid hormone/parathyroid hormone-related peptide receptor causing Blomstrand chondrodysplasia.". J. Clin. Endocrinol. Metab. 83 (9): 3365–8. doi:10.1210/jc.83.9.3373. PMID 9745456.  
  • Adams AE, Bisello A, Chorev M, et al. (1999). "Arginine 186 in the extracellular N-terminal region of the human parathyroid hormone 1 receptor is essential for contact with position 13 of the hormone.". Mol. Endocrinol. 12 (11): 1673–83. doi:10.1210/me.12.11.1673. PMID 9817594.  
  • Matsuzaki K, Katayama K, Takahashi Y, et al. (1999). "Human osteoclast-like cells are formed from peripheral blood mononuclear cells in a coculture with SaOS-2 cells transfected with the parathyroid hormone (PTH)/PTH-related protein receptor gene.". Endocrinology 140 (2): 925–32. doi:10.1210/en.140.2.925. PMID 9927325.  
  • Schipani E, Langman C, Hunzelman J, et al. (1999). "A novel parathyroid hormone (PTH)/PTH-related peptide receptor mutation in Jansen's metaphyseal chondrodysplasia.". J. Clin. Endocrinol. Metab. 84 (9): 3052–7. doi:10.1210/jc.84.9.3052. PMID 10487664.  
  • Karperien M, van der Harten HJ, van Schooten R, et al. (1999). "A frame-shift mutation in the type I parathyroid hormone (PTH)/PTH-related peptide receptor causing Blomstrand lethal osteochondrodysplasia.". J. Clin. Endocrinol. Metab. 84 (10): 3713–20. doi:10.1210/jc.84.10.3713. PMID 10523019.  
  • Watson PH, Fraher LJ, Natale BV, et al. (2000). "Nuclear localization of the type 1 parathyroid hormone/parathyroid hormone-related peptide receptor in MC3T3-E1 cells: association with serum-induced cell proliferation.". Bone 26 (3): 221–5. doi:10.1016/S8756-3282(99)00264-1. PMID 10709993.  
  • Truneh A, Sharma S, Silverman C, et al. (2000). "Temperature-sensitive differential affinity of TRAIL for its receptors. DR5 is the highest affinity receptor.". J. Biol. Chem. 275 (30): 23319–25. doi:10.1074/jbc.M910438199. PMID 10770955.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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