The Full Wiki

More info on Parathyroid hormone receptor 2

Parathyroid hormone receptor 2: Wikis

Advertisements

Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.

Encyclopedia

From Wikipedia, the free encyclopedia

edit
Parathyroid hormone receptor 2
Identifiers
Symbols PTHR2;
External IDs OMIM601469 MGI2180917 HomoloGene3701 IUPHAR: PTH2 GeneCards: PTHR2 Gene
RNA expression pattern
PBB GE PTHR2 206772 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5746 213527
Ensembl ENSG00000144407 ENSMUSG00000025946
UniProt P49190 Q8BUM8
RefSeq (mRNA) NM_005048 NM_139270
RefSeq (protein) NP_005039 NP_644676
Location (UCSC) Chr 2:
208.98 - 209.07 Mb
Chr 1:
65.25 - 65.32 Mb
PubMed search [1] [2]

Parathyroid hormone receptor 2, also known as PTH2, is a human protein encoded by the PTHR2 gene.[1]

The protein encoded by this gene is a member of the G-protein coupled receptor family 2. This protein is a receptor for parathyroid hormone (PTH). This receptor is more selective in ligand recognition and has a more specific tissue distribution compared to parathyroid hormone receptor 1 (PTHR1). It is activated only by PTH and not by parathyroid hormone-like hormone (PTHLH) and is particularly abundant in brain and pancreas.[1]

Contents

See also

References

Further reading

  • Usdin TB, Gruber C, Bonner TI (1995). "Identification and functional expression of a receptor selectively recognizing parathyroid hormone, the PTH2 receptor.". J. Biol. Chem. 270 (26): 15455–8. doi:10.1074/jbc.270.26.15455. PMID 7797535.  
  • Usdin TB, Modi W, Bonner TI (1997). "Assignment of the human PTH2 receptor gene (PTHR2) to chromosome 2q33 by fluorescence in situ hybridization.". Genomics 37 (1): 140–1. doi:10.1006/geno.1996.0532. PMID 8921382.  
  • Clark JA, Bonner TI, Kim AS, Usdin TB (1998). "Multiple regions of ligand discrimination revealed by analysis of chimeric parathyroid hormone 2 (PTH2) and PTH/PTH-related peptide (PTHrP) receptors.". Mol. Endocrinol. 12 (2): 193–206. doi:10.1210/me.12.2.193. PMID 9482662.  
  • Hoare SR, Clark JA, Usdin TB (2000). "Molecular determinants of tuberoinfundibular peptide of 39 residues (TIP39) selectivity for the parathyroid hormone-2 (PTH2) receptor. N-terminal truncation of TIP39 reverses PTH2 receptor/PTH1 receptor binding selectivity.". J. Biol. Chem. 275 (35): 27274–83. doi:10.1074/jbc.M003910200. PMID 10854439.  
  • John MR, Arai M, Rubin DA, et al. (2002). "Identification and characterization of the murine and human gene encoding the tuberoinfundibular peptide of 39 residues.". Endocrinology 143 (3): 1047–57. doi:10.1210/en.143.3.1047. PMID 11861531.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Seeliger S, Hausberg M, Eue I, et al. (2003). "The parathyroid hormone-2 receptor is expressed on human leukocytes and down-regulated in hyperparathyroidism.". Clin. Nephrol. 59 (6): 429–35. PMID 12834174.  
  • Bisello A, Manen D, Pierroz DD, et al. (2004). "Agonist-specific regulation of parathyroid hormone (PTH) receptor type 2 activity: structural and functional analysis of PTH- and tuberoinfundibular peptide (TIP) 39-stimulated desensitization and internalization.". Mol. Endocrinol. 18 (6): 1486–98. doi:10.1210/me.2003-0487. PMID 14988434.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Mahon MJ, Shimada M (2005). "Calmodulin interacts with the cytoplasmic tails of the parathyroid hormone 1 receptor and a sub-set of class b G-protein coupled receptors.". FEBS Lett. 579 (3): 803–7. doi:10.1016/j.febslet.2004.12.056. PMID 15670850.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Advertisements

Advertisements






Got something to say? Make a comment.
Your name
Your email address
Message