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Systematic (IUPAC) name
CAS number 555-57-7
ATC code C02KC01 C02LL01
PubChem 4688
Chemical data
Formula C 11H13N 
Mol. mass 159.23 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?
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Pargyline (Eutonyl) is a monoamine oxidase B (MAO-B) inhibitor.[1] It has antihypertensive effects.[2]


It functions by inhibiting the metabolism of catecholamines and tyramine within presynaptic nerve terminals. Patients taking pargyline must avoid concurrent consumption of tyramine-containing foods such as blue cheese and beer, as this can lead to a hypertensive crisis.[3]


  1. ^ Murphy DL, Karoum F, Pickar D, et al. (1998). "Differential trace amine alterations in individuals receiving acetylenic inhibitors of MAO-A (clorgyline) or MAO-B (selegiline and pargyline)". J. Neural Transm. Suppl. 52: 39–48. PMID 9564606.  
  2. ^ Fuentes JA, Ordaz A, Neff NH (July 1979). "Central mediation of the antihypertensive effect of pargyline in spontaneously hypertensive rats". Eur. J. Pharmacol. 57 (1): 21–7. PMID 477738.  
  3. ^ Tulane University School of Medicine Department of Pharmacology: Autonomic Drug Profile handout, October 2006


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