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Paul Ehrlich

Paul Ehrlich
Born 14 March 1854 (1854-03-14)
Strehlen, Lower Silesia, German Kingdom of Prussia
Died 20 August 1915 (1915-08-21) (aged 61)
Bad Homburg, Hesse, Germany
Citizenship Germany
Fields Immunology
Known for autoimmunity
Notable awards Nobel Prize in Physiology or Medicine ( 1908)

Paul Ehrlich (14 March 1854 – 20 August 1915) was a German scientist in the fields of hematology, immunology, and chemotherapy, and Nobel laureate. He is noted for curing syphilis and for his research in autoimmunity, calling it "horror autotoxicus". He coined the term "chemotherapy" and popularized the concept of a "magic bullet".

Contents

Biography

Early years

Paul Ehrlich was born into a Jewish family in Strehlen, in the German Kingdom of Prussia, Province of Silesia, (now in Poland). As a schoolboy and student of medicine he was interested in staining microscopic tissue substances.

Research

In his dissertation at the University of Leipzig, he picked up the topic again ("Contributions to the Theory and Practice of Histological Staining", Beiträge zur Theorie und Praxis der histologischen Färbung). He married Hedwig Pinkus (then aged 19) in 1883. The couple had two daughters, named Stephanie and Marianne. After his clinical education and habilitation ("The Need of the Organism for Oxygen ", Das Sauerstoffbedürfnis des Organismus) at the Charité in Berlin in 1886 he received a call from Robert Koch to join the Institute for Infectious Diseases in Berlin (1891).

Ehrlich spent two years in Egypt, recovering from tuberculosis. Thereafter he worked with his friend Emil Adolf von Behring on the development of the diphtheria serum.

Dr Paul Ehrlich & Dr Hata Sahachiro

These works inspired Ehrlich's famous side-chain theory (Seitenkettentheorie) from 1897. This theory explained the effects of serum and enabled measurement of the amount of antigen. In 1896 Ehrlich became the director of the newly founded Institute of Serum Research and Examination (Institut für Serumforschung und Serumprüfung) in Steglitz (Berlin). In 1899 the institute was moved to Frankfurt (Main) and extended into the Royal Institute of Experimental Therapy (Institut für experimentelle Therapie). Here Ehrlich researched chemotherapy and infectious diseases. In 1904 Ehrlich became honorary professor of the University of Göttingen.[1]

Ehrlich received the Nobel Prize for Medicine together with Ilya Ilyich Mechnikov in 1908. In 1906 he discovered the structural formula of atoxyl, a chemical compound which had been shown to be able to treat sleeping sickness. Following this discovery, he tried to create a less toxic version of the medicament. In 1909 he and his student Sahachiro Hata developed Salvarsan, a treatment effective against syphilis.

Personal life

Erlich's daughter Marianne was married to the great German-Jewish mathematician Edmund Landau. Ehrlich died of a stroke in Bad Homburg in 1915, age 61. He is buried in the Juedischer Friedhof on Rat Beil Straße in Frankfurt am Main, Germany.

Legacy

1996 series 200 Deutsche Mark banknote

His life is depicted in the movie Dr. Ehrlich's Magic Bullet, which focused on Salvarsan (arsphenamine, "compound 606"), his cure for syphilis. His work illuminated the existence of the blood-brain barrier.

The "magic bullet" concept comes from the experience of 19th century German chemists with selectively staining tissues for histological examination, and in particular, selectively staining bacteria (Ehrlich was an exceptionally gifted histological chemist, and invented the precursor technique to Gram staining bacteria). Ehrlich reasoned that if a compound could be made that selectively targeted a disease-causing organism, then a toxin for that organism could be delivered along with the agent of selectivity. Hence, a "magic bullet" would be created that killed only the organism targeted.

A problem with the use of the magic bullet concept as it emerged from its histological roots is that people confused the dye with the agent of tissue selectivity and antibiotic activity. Prontosil, a sulfa drug whose active component is sulfanilamide, is a classic example of the fact that color is not essential to antibacterial activity.

The concept of a "magic bullet" was fully realized with the invention of monoclonal antibodies.

Paul Ehrlich's life and achievements were filmed 1940 in Hollywood by William Dieterle in Dr. Ehrlich’s Magic Bullet with Edward G. Robinson in the title role.

See also

References

  1. ^ Herman A. Metz. Solving medical mysteries by help of animals. The New York Times, 28 January 1912
This article incorporates information from the equivalent article on the German Wikipedia.

External links


Simple English

Paul Ehrlich
File:Paul
Paul Ehrlich
BornMarch 14, 1854
Strehlen, Upper Silesia, Germany
DiedAugust 20, 1915
Bad Homburg, Germany
NationalityGerman
FieldImmunology
InstitutionsGoettingen University,
Königliches Institut für experimentelle Therapie
Alma materUniversities of Breslau, Strassburg, Leipzig
Notable prizesNobel Prize in Physiology or Medicine (1908)

Paul Ehrlich (March 14, 1854 - August 20, 1915) is an German doctor.[1] He won the 1908 Nobel Prize in Physiology or Medicine, along with Ilya Ilyich Mechnikov, for finding out how immunity fights disease.[2]

References








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