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Pentolinium: Wikis

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Pentolinium
Systematic (IUPAC) name
1-methyl-1-[5-(1-methylpyrrolidin-1-ium-1-yl)pentyl]pyrrolidin-1-ium
Identifiers
CAS number 52-62-0
ATC code  ?
PubChem 5850
ChemSpider 5641
Chemical data
Formula C15H32N2
Mol. mass 240.43 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

Pentolinium is a ganglionic blocking agent which acts as a nicotinic acetylcholine receptor antagonist. It can be used as an antihypertensive drug during surgery or to control hypertensive crises. It works by binding to the acetylcholine receptor of adrenergic nerves and thereby inhibiting the release of noradrenaline and adrenaline. Blocking this receptor leads to smooth muscle relaxation and vasodilatation. Pentolinium can be given orally, injected intramuscularly or administered intravenously.

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