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Peptidyl transferase: Wikis

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From Wikipedia, the free encyclopedia

The Peptidyl transferase is an aminoacyltransferase (EC 2.3.2.12) as well as the primary enzymatic function of the ribosome which forms peptide links between adjacent amino acids using tRNAs during the translation process of protein biosynthesis.

Peptidyl transferase activity is carried out by the ribosome.

  • In Bacteria, the 50S (23S component) ribosome subunit contains the peptidyl transferase component and acts as a ribozyme.
  • In eukaryotic cells, the 60S (28S component) ribosome subunit contains the peptidyl transferase component and acts as the ribozyme.

Peptidyl transferases are not limited to translation but there are relatively few enzymes with this function.

Contents

Antibiotic target

The following protein synthesis inhibitors target peptidyl transferase:

See also

References

  1. ^ Gu Z, Harrod R, Rogers EJ, Lovett PS (June 1994). "Anti-peptidyl transferase leader peptides of attenuation-regulated chloramphenicol-resistance genes". Proc. Natl. Acad. Sci. U.S.A. 91 (12): 5612–6. doi:10.1073/pnas.91.12.5612. PMID 7515506.  
  2. ^ Long, Katherine S (April 2006). "Interaction of Pleuromutilin Derivatives with the Ribosomal Peptidyl Transferase Center". Antimicrobial Agents and Chemotherapy 50 (4): 1458–1462. doi:10.1128/AAC.50.4.1458-1462.2006. PMID 16569865. PMC 1426994. http://aac.asm.org/cgi/reprint/50/4/1458.pdf.  
  3. ^ Protein synthesis inhibitors: macrolides mechanism of action animation. Classification of agents Pharmamotion. Author: Gary Kaiser. The Community College of Baltimore County. Retrieved on July 31, 2009

External links

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