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Pericine: Wikis


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Systematic (IUPAC) name
CAS number 84638-28-8
ATC code none
PubChem 6440735
Chemical data
Formula C 19H22N2  
Mol. mass 278.391 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status Legal
Routes Oral

Pericine is one of a number of indole alkaloids found in the tree Picralima nitida, commonly known as Akuamma. The dried seeds from this plant are used in traditional medicine throughout West Africa, particularly in Ghana as well as in the Ivory Coast and Nigeria. As with some other alkaloids from this plant such as akuammine, pericine has been shown to bind to mu opioid receptors, and has an IC50 of 0.6μmol, around 6x more potent than codeine when tested in the same assay.[1] However it may also have convulsant effects.[2]


  1. ^ Arens H, Borbe HO, Ulbrich B, Stöckigt J. Detection of Pericine, a New CNS-active Indole Alkaloid from Picralima nitida Cell Suspension Culture by Opiate Receptor Binding Studies. Planta Medica. 1982 Dec;46(12):210-4. PMID 17396975
  2. ^ Margaret F. Roberts, Michael Wink. Alkaloids: Biochemistry, Ecology, and Medicinal Applications. pp68-69. ISBN 9780306454653


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