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Phenaridine: Wikis


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Systematic (IUPAC) name
CAS number 42045-97-6
ATC code none
PubChem 162056
Chemical data
Formula C 24H32N2O 
Mol. mass 364.52 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

Phenaridine (2,5-Dimethylfentanyl) is an opioid analgesic that is an analogue of fentanyl. It was developed in 1972[1], and is used for surgical anasthesia.[2][3]

Phenaridine has similar effects to fentanyl. It is slightly less potent than fentanyl in rats[1]. Side effects of fentanyl analogues are similar to those of fentanyl itself, which include itching, nausea and potentially serious respiratory depression which can be life-threatening.[4]


  1. ^ a b Riley NT, Hale DB, Wilson MV. 4-Anilidopiperidine Analgesics I: Synthesis and Analgesic Activity of Certain Ring-Methylated 1-Substituted 4-Propananilidopiperidines. J. Pharm. Sci 62(6): 983 (1973)
  2. ^ Osipova NA, Petrova VV, Novikov GA, Dolgopolova TV, Zhukova OI, Mel'nikova ZL, Smolina TA. The new Soviet narcotic analgesic phenaridine as a component of general anesthesia during cancer surgery. (Russian). Anesteziologiia i Reanimatologiia. 1991 Jan-Feb;(1):42-6.
  3. ^ Vlasenko EV, Durgarian LK, Azlivian AS, Sarukhanian KV. The evaluation of the analgesic action of phenaridine when combined with agents used in anesthesiological practice. (Russian). Farmakologiia i Toksikologiia. 1991 May-Jun;54(3):17-20.
  4. ^ Buniatian AA, Seleznev MN, Flerov EV, Iavorovskii AG, Sarukhanian KV, Vyzhigina MA. Balanced anesthesia using the new Russian analgesic fenaridina in cardiovascular surgery and its effect on hemodynamics and respiration. (Russian). Anesteziologiia i Reanimatologiia. 1993 Sep-Oct;(5):3-8.


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