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Phenindamine
Systematic (IUPAC) name
2-methyl-9-phenyl-2,3,4,9-tetrahydro-1H-indeno[2,1- c]pyridine
Identifiers
CAS number 82-88-2
ATC code R06AX04
PubChem 11291
Chemical data
Formula C 19H19N 
Mol. mass 261.361 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?
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Phenindamine (Nolahist, Thephorin) is an antihistamine and anticholinergic closely related to cyproheptadine which is used to treat symptoms of the common cold and allergies, such as sneezing, itching, rashes, and hives. Its efficacy against some symptoms of opioid withdrawal was researched in the 1950s and 1960s in a number of countries; William S. Burroughs' book Junky mentions this technique. Like many other first-generation antihistamines, phenindamine has useful potentiating effects on many narcotic analgesics and is even more useful with those opioids which release histamine when in the body.

Nolahist was originally manufactured in the USA by Carnrick Laboratories, and later by Amarin Pharmaceuticals. When that company ceased its American operations, its product line was acquired by Valeant, but they declined to resume manufacturing Nolahist. The last produced lot bore an expiration date of 10/2005, and the product is no longer available.

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