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Pheniramine: Wikis

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Pheniramine
Systematic (IUPAC) name
N,N-dimethyl-3-phenyl-3-pyridin-2-yl-propan-1-amine
Identifiers
CAS number 86-21-5
ATC code R06AB05
PubChem 4761
Chemical data
Formula C 16H20N2  
Mol. mass 240.343 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism Hepatic hydroxylation, demethylation and glucuronidation
Half life  ?
Excretion Renal
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes Oral
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Pheniramine (Avil) is an antihistamine with anticholinergic properties used to treat allergic conditions such as hay fever or urticaria. It has relatively strong sedative effects, and may sometimes be used off-label as an over-the-counter sleeping pill in a similar manner to other sedating antihistamines such as diphenhydramine.

Pheniramine is generally sold in combination with other medications, rather than as a stand-alone drug, although some formulations are available containing pheniramine by itself. As an example, Neo Citran contains pheniramine.

Chemical relatives

Derivatives of pheniramine include chlorpheniramine, dexchlorpheniramine, dexbrompheniramine, deschlorpheniramine, triprolidine, and brompheniramine. Two other halogenated derivatives, iodopheniramine and fluorpheniramine, are currently in use for research on combination therapies for malaria and some cancers. The halogenation of pheniramine increases its potency by 20-fold.

References

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