The Full Wiki

More info on Phenomorphan

Phenomorphan: Wikis

Advertisements

Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.

Encyclopedia

From Wikipedia, the free encyclopedia

Phenomorphan
Systematic (IUPAC) name
17-(2-phenylethyl) morphinan- 3-ol
Identifiers
CAS number 468-07-5
ATC code none
PubChem 5362458
Chemical data
Formula C 24H29NO 
Mol. mass 347.493 g/mol
Synonyms (-)-3-hydroxy- N- (2-phenylethyl) morphinan
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status Class A (UK) Schedule I (US)
Routes  ?

Phenomorphan is an opioid analgesic. It is not currently used in medicine, but has similar side effects to other opiates, which include itching, nausea and respiratory depression.

Phenomorphan is a highly potent drug due to the N-phenethyl group which boosts affinity to the μ-opioid receptor, and so phenomorphan is around 10x more potent than levorphanol, which is itself 6-8x the potency of morphine. Other analogues where the N-(2-phenylethyl) group has been replaced by other aromatic rings are even more potent, with the N-(2-(2-furyl)ethyl) and the N-(2-(2-thienyl)ethyl) analogues being 60x and 45x stronger than levorphanol respectively.[1]

References

  1. ^ Hellerbach J, Schnider O, Besendorf H, Pellmont B. Synthetic Analgesics. Part IIA. Morphinans. Pergamon Press, 1966.
Advertisements

Advertisements






Got something to say? Make a comment.
Your name
Your email address
Message