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Phenomorphan: Wikis


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Systematic (IUPAC) name
17-(2-phenylethyl) morphinan- 3-ol
CAS number 468-07-5
ATC code none
PubChem 5362458
Chemical data
Formula C 24H29NO 
Mol. mass 347.493 g/mol
Synonyms (-)-3-hydroxy- N- (2-phenylethyl) morphinan
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status Class A (UK) Schedule I (US)
Routes  ?

Phenomorphan is an opioid analgesic. It is not currently used in medicine, but has similar side effects to other opiates, which include itching, nausea and respiratory depression.

Phenomorphan is a highly potent drug due to the N-phenethyl group which boosts affinity to the μ-opioid receptor, and so phenomorphan is around 10x more potent than levorphanol, which is itself 6-8x the potency of morphine. Other analogues where the N-(2-phenylethyl) group has been replaced by other aromatic rings are even more potent, with the N-(2-(2-furyl)ethyl) and the N-(2-(2-thienyl)ethyl) analogues being 60x and 45x stronger than levorphanol respectively.[1]


  1. ^ Hellerbach J, Schnider O, Besendorf H, Pellmont B. Synthetic Analgesics. Part IIA. Morphinans. Pergamon Press, 1966.


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