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Phenoxypropazine: Wikis


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Phenoxypropazine
Systematic (IUPAC) name
(1-methyl-2-phenoxy-ethyl)hydrazine
Identifiers
CAS number 3818-37-9
ATC code none
PubChem 71467
ChemSpider 64548
Chemical data
Formula C9H14N2O 
Mol. mass 166.22 g/mol
Therapeutic considerations
Pregnancy cat.  ?
Legal status Prescription only
Routes Oral

Phenoxypropazine (trade name Drazine) is an irreversible and nonselective monoamine oxidase inhibitor (MAOI) of the hydrazine chemical class that was introduced as an antidepressant in 1961, but was subsequently withdrawn in 1966 due to hepatotoxicity concerns.[1][2][3][4][5]

See also

References

  1. ^ LEAHY MR, ROSE JT, PLOWMAN R (April 1963). "A preliminary study of phenoxypropazine in the treatment of depression". The American Journal of Psychiatry 119: 986–7. PMID 13928824. http://ajp.psychiatryonline.org/cgi/pmidlookup?view=long&pmid=13928824. 
  2. ^ IMLAH NW (May 1963). "Preliminary report on phenoxypropazine". The American Journal of Psychiatry 119: 1091–2. PMID 13956423. http://ajp.psychiatryonline.org/cgi/pmidlookup?view=long&pmid=13956423. 
  3. ^ ROSE JT, LEAHY MR, PLOWMAN R (October 1963). "A comparison of phenoxypropazine and amitriptyline in depression". The American Journal of Psychiatry 120: 393–5. PMID 14069469. http://ajp.psychiatryonline.org/cgi/pmidlookup?view=long&pmid=14069469. 
  4. ^ ROSE JT (March 1964). "Phenoxypropazine and chlordiazepoxide in depression". The American Journal of Psychiatry 120: 899–900. PMID 14129290. http://ajp.psychiatryonline.org/cgi/pmidlookup?view=long&pmid=14129290. 
  5. ^ MCWHINNEY IR, MORRELL DC (January 1965). "Treatment of mild endogenous depression with a monoamine oxidase inhibitor: a controlled trial in general practice". The Journal of the College of General Practitioners 9: 95–9. PMID 14254271. 







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