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Phenylethanolamine N-methyltransferase: Wikis

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phenylethanolamine N-methyltransferase
Identifiers
Symbol PNMT
Alt. symbols PENT
Entrez 5409
HUGO 9160
OMIM 171190
RefSeq NM_002686
UniProt P11086
Other data
EC number 2.1.1.28
Locus Chr. 17 q21-q22

Phenylethanolamine N-methyltransferase (PNMT) is an enzyme found in the adrenal medulla that converts Norepinephrine (Noradrenaline) to Epinephrine (Adrenaline).

PNMT is positively influenced by cortisol, which is produced in the adrenal cortex.

S-adenosyl-L-methionine ('SAM') is a required cofactor.[1]

PNMT converts the last step in the synthesis of epinephrine


References

  1. ^ Wong DL, Lesage A, Siddall B, Funder JW (November 1992). "Glucocorticoid regulation of phenylethanolamine N-methyltransferase in vivo". The FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology 6 (14): 3310–5. PMID 1426768. http://www.fasebj.org/cgi/content/abstract/6/14/3310.  

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