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Crystallographic structure of yeast Pho4 homodimer (cyan and green) complexed with DNA (brown).[1]
Symbol Pho4
Alt. symbols YFR034C
Entrez 850594
PDB 1a0a
RefSeq NP_116692
UniProt P07270
Other data

Pho4 is a basic-helix-loop-helix (bHLH) transcription factor found in S. cerevisiae and other yeasts.[2]

The Pho4 homodimer binds to DNA sequences containing the bHLH binding site 5'-CACGTG-3'.[3] This sequence is found in the promoters of genes upregulated in response to phosphate availability such as the PHO5 gene.[4]


  1. ^ PDB 1a0a; Shimizu T, Toumoto A, Ihara K, Shimizu M, Kyogoku Y, Ogawa N, Oshima Y, Hakoshima T (August 1997). "Crystal structure of PHO4 bHLH domain-DNA complex: flanking base recognition". EMBO J. 16 (15): 4689–97. doi:10.1093/emboj/16.15.4689. PMID 9303313.  
  2. ^ Berben G, Legrain M, Gilliquet V, Hilger F (1990). "The yeast regulatory gene PHO4 encodes a helix-loop-helix motif". Yeast 6 (5): 451–4. doi:10.1002/yea.320060510. PMID 2220078.  
  3. ^ Shao D, Creasy CL, Bergman LW (February 1998). "A cysteine residue in helixII of the bHLH domain is essential for homodimerization of the yeast transcription factor Pho4p". Nucleic Acids Res. 26 (3): 710–4. doi:10.1093/nar/26.3.710. PMID 9443961.  
  4. ^ Ogawa N, Oshima Y (May 1990). "Functional domains of a positive regulatory protein, PHO4, for transcriptional control of the phosphatase regulon in Saccharomyces cerevisiae". Mol. Cell. Biol. 10 (5): 2224–36. PMID 2183025. PMC 360570.  

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