The Phoenix Film Critics Society Award for Best Performance by an Actress in a Leading Role is an award given by the Phoenix Film Critics Society to honor the finest achievements in filmmaking.
| Year | Winner | Film | Role |
|---|---|---|---|
| 2000 | Ellen Burstyn | Requiem for a Dream | Sara Goldfarb |
| 2001 | Nicole Kidman | The Others | Grace Stewart |
| 2002 | Julianne Moore | Far from Heaven | Cathy Whitaker |
| 2003 | Naomi Watts | 21 Grams | Cristina Peck |
| 2004 | Hilary Swank | Million Dollar Baby | Maggie Fitzgerald |
| 2005 | Felicity Huffman | Transamerica | Stanley Schupak/Bree Osbourne |
| 2006 | Helen Mirren | The Queen | Queen Elizabeth II |
| 2007 | Julie Christie | Away from Her | Fiona Anderson |
| 2008 | Meryl Streep | Doubt | Aloysius Beauvier |
| 2009 | Meryl Streep | Julie & Julia | Julia Child |
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