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Physalaemin
Physalaemin.svg
Identifiers
CAS number 2507-24-6
PubChem 17268
MeSH Physalaemin
Properties
Molecular formula C58H84N14O16S
Molar mass 1265.44 g/mol
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Physalaemin is a tachykinin peptide obtained from the Physalaemus frog, closely related to substance P. Its structure was first elucidated in 1964.[1][2]

Like all tachykinins, physalaemin is a sialagogue (increases salivation) and a potent vasodilator with hypotensive effects.[3]

References

  1. ^ Erspaemer V, Anastasi A, Bertaccini G, Cei JM (1964). "Structure and pharmacological actions of physalaemin, the main active polypeptide of the skin of Physalaemus fuscumaculatus". Experientia 20 (9): 489–90. doi:10.1007/BF02154064. PMID 5857249.  
  2. ^ Anastasi A, Erspamer V, Cei JM (1964). "Isolation and amino acid sequence of physalaemin, the main active polypeptide of the skin of Physalaemus fuscumaculatus". Arch Biochem Biophys 108: 341–8. doi:10.1016/0003-9861(64)90395-9. PMID 14240587.  
  3. ^ Severini C, Improta G, Falconieri-Erspamer G, Salvadori S, Erspamer V (2002). "The tachykinin peptide family". Pharmacol Rev 54 (2): 285–322. doi:10.1124/pr.54.2.285. PMID 12037144.   Free full text

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