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Pirandamine: Wikis

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Systematic (IUPAC) name
CAS number 57932-12-4
ATC code none
PubChem 431429
ChemSpider 381558
Chemical data
Formula C17H23NO 
Mol. mass 257.37 g/mol
Therapeutic considerations
Pregnancy cat.  ?
Legal status

Pirandamine is a tricyclic derivative which acts as a selective serotonin reuptake inhibitor (SSRI).[1][2][3] It was investigated in the 1970s as a potential antidepressant but clinical development wasn't commenced and it was never marketed.[1] Pirandamine is structurally related to tandamine, which, in contrast, is a selective norepinephrine reuptake inhibitor.[1][3]

See also


  1. ^ a b c Pugsley T, Lippmann W (May 1976). "Effects of tandamine and pirandamine, new potential antidepressants, on the brain uptake of norepinephrine and 5-hydroxytryptamine and related activities". Psychopharmacology 47 (1): 33–41. PMID 1085452. 
  2. ^ Lippmann W, Pugsley TA (August 1976). "Pirandamine, a relatively selective 5-hydroxytryptamine uptake inhibitor". Pharmacological Research Communications 8 (4): 387–405. PMID 1088377. 
  3. ^ a b Lippmann W, Seethaler K (April 1977). "Effects of tandamine and pirandamine, selective blockers of biogenic amine uptake mechanisms, on gastric acid secretion and ulcer formation in the rat". Life Sciences 20 (8): 1393–400. PMID 853871. 

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