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Pirenzepine: Wikis


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Systematic (IUPAC) name
CAS number 28797-61-7
ATC code A02BX03
PubChem 4848
DrugBank APRD00515
Chemical data
Formula C19H21N5O2 
Mol. mass 351.403 g/mol
Therapeutic considerations
Pregnancy cat.  ?
Legal status
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Pirenzepine (Gastrozepin) is used in the treatment of peptic ulcers, as it reduces gastric acid secretion and reduces muscle spasm. It is in a class of drugs known as muscarinic receptor antagonists - acetylcholine being the neurotransmitter of the parasympathetic nervous system which initiates the rest-and-digest state (as opposed to fight-or-flight), the result being an increase in gastric motility and digestion. It has no effects on the brain and spinal cord as it cannot diffuse through the blood-brain barrier.

Pirenzepine has been investigated for use in myopia control.[1]


  1. ^ Czepita D (2005). "Fundamentals of modern treatment of myopia". Ann Acad Med Stetin 51 (2): 5–9. PMID 16519089. 


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