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Piribedil: Wikis


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Systematic (IUPAC) name
CAS number 3605-01-4
ATC code N04BC08
PubChem 4850
Chemical data
Formula C 16H18N4O2  
Mol. mass 298.340 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life 1.7 – 6.9 hours
Excretion Renal (68%) and biliary (25%)
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes Oral

Piribedil (trade names Trivastal, Pronoran, Trastal, Trivastan) is a piperazine derivative and selective dopamine D2 and D3 receptor agonist with additional α2-adrenergic antagonist properties.



Additional research and uses

The drug has been shown to enhance working memory capacities in normal aging adults.[1]

In age-related memory impairment, it has a positive effect on psychophysiological state of elderly people, improving memory and attention and increasing the velocity of psychomotor reactions and lability of nervous processes.[2]

It enhances cognitive skill learning in healthy older adults.[3]

It showed a positive effect in restless legs syndrome [4]



Parkinson's disease

Administration of piribedil should be initiated with one tablet daily during the first week. Dosage should then be gradually increased every week until achieving the optimal therapeutic dose:

  • as monotherapy: three to five tablets in three to five doses daily.
  • in combination with L-dopa therapy: one to three tablets daily.

Other indications

One tablet daily at the end of the main meal. In severe cases: two tablets daily in two doses.

Adverse effects


Dopamine antagonists reduce the effect of piribedil.


At very high doses, piribedil has an emetic action on the chemoreceptor trigger zone (CTZ). Tablets will thus be rapidly rejected, which explains why no data are currently available concerning the risk of overdosage.

Receptor affinities

See also


  1. ^ Gierski, F.; Peretti, C.; Ergis, A. (30 January 2007). "Effects of the dopamine agonist piribedil on prefrontal temporal cortical network function in normal aging as assessed by verbal fluency". Progress in Neuro-Psychopharmacology and Biological Psychiatry 31 (1): 262–268. doi:10.1016/j.pnpbp.2006.06.017. PMID 16876301.   edit
  2. ^ Bochkarev, VK; Faĭzulloev, AZ; Avedisova, AS (2005). "Efficacy of pronoran in age-related memory impairment". Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova / Ministerstvo zdravookhraneniia i meditsinskoi promyshlennosti Rossiiskoi Federatsii, Vserossiiskoe obshchestvo nevrologov [i] Vserossiiskoe obshchestvo psikhiatrov 105 (2): 46–50. PMID 15792142.   edit
  3. ^ Peretti, C. S.; Gierski, F.; Harrois, S. (November 2004). "Cognitive skill learning in healthy older adults after 2 months of double-blind treatment with piribedil". Psychopharmacology 176 (2): 176–182. doi:10.1007/s00213-004-1869-8.   edit
  4. ^ Evidente, VG (May 2001). "Piribedil for restless legs syndrome: a pilot study". Movement disorders : official journal of the Movement Disorder Society 16 (3): 579–81. PMID 11391766.   edit
  5. ^ a b Schubert-Zsilavecz, M. "Piribedil" (in German). Neue Arzneimittel 2008.  

External links


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