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Pivagabine
Systematic (IUPAC) name
4-(2,2-dimethylpropanoylamino)butanoic acid
Identifiers
CAS number 69542-93-4
ATC code  ?
PubChem 68888
ChemSpider 62118
Chemical data
Formula C9H17NO3
Mol. mass 187.24 g/mol
Synonyms N-trimethylacetyl-4-aminobutyric acid
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status Uncontrolled
Routes Oral

Pivagabine (Tonerg) is an antidepressant and anxiolytic agent. It was introduced in Italy in 1997 for the treatment of maladaptive and depressive syndromes. Originally believed to function as a prodrug to GABA,[1] pivagabine is now believed to act via its inhibitory effects on corticotropin-releasing factor (CRF).[2][3][4][5]

See also

References

  1. ^ Bianchi M, Quadro G, Mourier G, Galzigna L (1983). "Pharmacokinetics and in vitro effects of a 4-aminobutyric acid derivative with anticonvulsant action". Pharmacology 27 (4): 237–40. PMID 6634934.  
  2. ^ Scapagnini U, Matera M (November 1997). "Effects of pivagabine on psychophysical performance and behavioural response in experimental models of stress". Arzneimittel-Forschung 47 (11A): 1310–4. PMID 9450154.  
  3. ^ Esposito G, Luparini MR (November 1997). Pivagabine: a novel psychoactive drug. 47. pp. 1306–9. PMID 9450153.  
  4. ^ Gerra G, Zaimovic A, Giusti F, et al. (July 2001). "Pivagabine effects on neuroendocrine responses to experimentally-induced psychological stress in humans". Behavioural Brain Research 122 (1): 93–101. PMID 11287080. http://linkinghub.elsevier.com/retrieve/pii/S0166-4328(01)00177-2.  
  5. ^ Serra M, Concas A, Mostallino MC, et al. (April 1999). "Antagonism by pivagabine of stress-induced changes in GABAA receptor function and corticotropin-releasing factor concentrations in rat brain". Psychoneuroendocrinology 24 (3): 269–84. PMID 10101733. http://linkinghub.elsevier.com/retrieve/pii/S0306-4530(98)00049-3.  







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