The Full Wiki

More info on Plateau potentials

Plateau potentials: Wikis


Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.


From Wikipedia, the free encyclopedia

Plateau potentials, also referred to as persistent inward currents (PICs), are a type of electrical behaviour seen by cells in the spinal cord. They are of particular importance to spinal motor systems. PICs are set up by the influence of descending monoaminergic reticulospinal pathways. Metabotropic neurotransmitters, via monoaminergic input such as 5-HT and norepinephrine, modulate the activity of dendritic L-type Calcium channels that allow a sustained, positive, inward current into the cell. This leads to a lasting depolarisation. In this state, the cell fires action potentials independent of synaptic input. The PICs can be turned off via the activation of high-frequency inhibitory input at which point the cell returns to a resting state. Plateau potentials are also seen in the cortical, and hippocampal pyramidal neurons. By iontophoretic, or two-photon glutamate uncaging experiments, these plateau potentials includes activities of voltage dependent calcium channels and NMDA receptors.


Svirskis et al. (2001) Electrotonic structure of motoneurons in the spinal cord of the turtle: inferences for the mechanisms of bistability. J. Neurophysiol. 85:391-398 (PMID: 11152739)

Suzuki T et al. (2008) A Plateau potential mediated by the activation of extrasynaptic NMDA receptors in rat hippocampal CA1 pyramidal neurons. EJ Neuroscience. 28:521-534

Major G et al. (2008) Spatiotemporally Graded NMDA Spike/Plateau Potentials in Basal Dendrites of Neocortical Pyramidal Neurons. J Neurophysiol. 99:2584-2601


Got something to say? Make a comment.
Your name
Your email address