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Polo kinase
Identifiers
EC number 2.7.11.21
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

In enzymology, a polo kinase (EC 2.7.11.21) is an kinase enzyme i.e. one that catalyzes the chemical reaction

ATP + a protein \rightleftharpoons ADP + a phosphoprotein

Thus, the two substrates of these enzymes are ATP and protein, whereas their two products are ADP and phosphoprotein.

These enzymes belongs to the family of transferases, specifically those transferring a phosphate group to the sidechain oxygen atom of serine or threonine residues in proteins (protein-serine/threonine kinases).

The systematic name of this [polo[-like] kinase] enzyme class is ATP:protein phosphotransferase (spindle-pole-dependent).

Examples and Other names in common use include Cdc5, Cdc5p, Plk, PLK, Plk1, Plo1, POLO kinase, polo serine-threonine kinase, polo-like kinase, polo-like kinase 1, serine/threonine-specific Drosophila kinase polo, and STK21.

These enzymes participate in 3 metabolic pathways: cell cycle, cell cycle - yeast, and progesterone-mediated oocyte maturation.

Structural studies

As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes 2OGQ, 2OJS, 2OJX, 2OU7, and 2OWB.

References

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Wiktionary

Up to date as of January 15, 2010

Definition from Wiktionary, a free dictionary

Contents

English

Etymology

Noun

Singular
Polo kinase

Plural
Polo kinases

Polo kinase (plural Polo kinases)

  1. (biochemistry) An enzyme that regulates cell cycle progression

Usage notes

  • Not always capitalized.

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