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Porfimer sodium
Systematic (IUPAC) name
CAS number 97067-70-4 87806-31-3 (porfimer sodium)
ATC code L01XD01
PubChem 57166
DrugBank APRD00078
Chemical data
Formula C 68H74N8O11 (for n=0) 
Mol. mass 1179.36 g/mol (for n=0)
Pharmacokinetic data
Bioavailability NA
Protein binding ~90%
Metabolism  ?
Half life 21.5 days (mean)
Excretion Fecal
Therapeutic considerations
Licence data

EU EMEA:linkUS FDA:link

Pregnancy cat. C(US)
Legal status -only (US)
Routes Intravenous

Porfimer sodium, sold as Photofrin, is a photosensitizer used in photodynamic therapy and radiation therapy and for palliative treatment of obstructing endobronchial non-small cell lung carcinoma and obstructing esophageal cancer.

Porfimer is a mixture of oligomers formed by ether and ester linkages of up to eight porphyrin units.[1]

It absorbs red light at 630nm.[2]

Approvals and indications

It was approved in Canada in 1993 for the treatment of bladder cancer[2]. It was approved in Japan in 1994 (for early stage lung cancer?)[2]. It was approved by the U.S. FDA in December 1995 esophageal cancer, and in 1998, it was approved for the treatment of early non-small cell lung cancer[2].

In August 2003 the FDA approved its use for Barrett's esophagus.[3]


External links

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