The Full Wiki

More info on Porfimer sodium

Porfimer sodium: Wikis


Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.

Encyclopedia

From Wikipedia, the free encyclopedia

Porfimer sodium
Systematic (IUPAC) name
 ?
Identifiers
CAS number 97067-70-4 87806-31-3 (porfimer sodium)
ATC code L01XD01
PubChem 57166
DrugBank APRD00078
Chemical data
Formula C 68H74N8O11 (for n=0) 
Mol. mass 1179.36 g/mol (for n=0)
Pharmacokinetic data
Bioavailability NA
Protein binding ~90%
Metabolism  ?
Half life 21.5 days (mean)
Excretion Fecal
Therapeutic considerations
Licence data

EU EMEA:linkUS FDA:link

Pregnancy cat. C(US)
Legal status -only (US)
Routes Intravenous

Porfimer sodium, sold as Photofrin, is a photosensitizer used in photodynamic therapy and radiation therapy and for palliative treatment of obstructing endobronchial non-small cell lung carcinoma and obstructing esophageal cancer.

Porfimer is a mixture of oligomers formed by ether and ester linkages of up to eight porphyrin units.[1]

It absorbs red light at 630nm.[2]

Approvals and indications

It was approved in Canada in 1993 for the treatment of bladder cancer[2]. It was approved in Japan in 1994 (for early stage lung cancer?)[2]. It was approved by the U.S. FDA in December 1995 esophageal cancer, and in 1998, it was approved for the treatment of early non-small cell lung cancer[2].

In August 2003 the FDA approved its use for Barrett's esophagus.[3]

References

External links








Got something to say? Make a comment.
Your name
Your email address
Message