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Prenylamine: Wikis


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Systematic (IUPAC) name
CAS number  ?
ATC code C01DX02
PubChem 9801
Chemical data
Formula C 24H27N 
Mol. mass 329.48 g/mol
Synonyms N-(3,3-diphenylpropyl)amphetamine
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status Uncontrolled
Routes Oral

Prenylamine (Segontin) is a calcium channel blocker of the amphetamine chemical class which is used as a vasodilator in the treatment of angina pectoris. It has been shown to partially metabolize to amphetamine and can cause false positives for it in drug tests.[1][2][3] Prenylamine also appears to act as a vesicular monoamine transporter inhibitor, and has been demonstrated to deplete vesicular monoamine neurotransmitter stores similarly to reserpine.[4]


  1. ^ Kraemer T, Roditis SK, Peters FT, Maurer HH (March 2003). "Amphetamine concentrations in human urine following single-dose administration of the calcium antagonist prenylamine-studies using fluorescence polarization immunoassay (FPIA) and GC-MS". Journal of Analytical Toxicology 27 (2): 68–73. doi:NO_DOI. PMID 12669999.  
  2. ^ Musshoff F (February 2000). "Illegal or legitimate use? Precursor compounds to amphetamine and methamphetamine". Drug Metabolism Reviews 32 (1): 15–44. doi:10.1081/DMR-100100562. PMID 10711406.  
  3. ^ Cody JT (May 2002). "Precursor medications as a source of methamphetamine and/or amphetamine positive drug testing results". Journal of Occupational and Environmental Medicine / American College of Occupational and Environmental Medicine 44 (5): 435–50. PMID 12024689.  
  4. ^ Bagchi SP (1990). "Antidopaminergic action of verapamil and several other drugs: inactivation of vesicular dopamine". Life Sciences 46 (12): 857–63. PMID 1969603.  


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