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Prodilidine: Wikis


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Systematic (IUPAC) name
1,2-dimethyl-3-phenylpyrrolidin-3-yl propionate
CAS number 3734-17-6
ATC code none
PubChem 19514
Chemical data
Formula C 15H21NO2  
Mol. mass 247.333 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

Prodilidine is an opioid analgesic which is a ring-contracted analogue of prodine. It has around the same efficacy as codeine, but is only around 1/3rd the potency, and has little abuse potential.[1][2][3][4][5]


  1. ^ Fraser HF. Addictiveness of 1,2-dimethyl,3-phenyl,3-propionoxy pyrrolidine hydrochloride (ARC I-O-1) UNODC Bulletin on Narcotics 1964 Issue 1.
  2. ^ Splitter SR. Treatment of pain in patients with a new nonnarcotic analgesic, prodilidine hydrochloride (Cogesic). Current Therapeutic Research, Clinical and Experimental. 1961 Nov;3:472-7. PMID 13915874
  3. ^ Kissel JW, Albert JR, Boxill GC. The pharmacology of prodilidine hydrochloride, a new analgetic agent. Journal of Pharmacology and Experimental Therapeutics. 1961 Dec;134:332-40. PMID 14456453
  4. ^ Weikel JH Jr, Labudde JA. Absorption, excretion and fate of prodilidine. Journal of Pharmacology and Experimental Therapeutics. 1962 Dec;138:392-8. PMID 13999550
  5. ^ Batterman RC, Mouratoff GJ, Kaufman JE. Prodilidine Hydrochloride: A new moderately potent analgesic. American Journal of the Medical Sciences. 1964 Jan;247:62-8. PMID 14106881


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