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Proglumetacin: Wikis

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Proglumetacin
Systematic (IUPAC) name
3-{4-[2-({[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1 H-indol-3-yl]acetyl}oxy)ethyl]piperazin-1-yl}propyl N2-benzoyl-N,N-dipropyl-α-glutaminate
Identifiers
CAS number 57132-53-3 59209-40-4 (maleate)
ATC code M01AB14
PubChem 4921
Chemical data
Formula C 46H58ClN5O8  
Mol. mass 844.43442 g/mol
Synonyms 3-[4-[2-[2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetyl]oxyethyl]piperazin-1-yl]propyl 4-(benzoylamino)-5-(dipropylamino)-5-oxopentanoate
Pharmacokinetic data
Bioavailability  ?
Metabolism Hepatic. Undergoes enterohepatic recirculation
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

Proglumetacin (usually as the maleate salt, trade names Afloxan, Protaxon and Proxil) is a non-steroidal anti-inflammatory drug. It is metabolized in the body to indometacin and proglumide,[1] a drug with antisecretory effects that helps prevent injury to the stomach lining.

References

  1. ^ Setnikar I, Arigoni R, Chisté R, Makovec F, Revel L (1987). "Plasma levels of proglumetacin and its metabolites after intravenous or oral administration in the dog". Arzneimittel-Forschung 37 (6): 698–702. PMID 3663267.  
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