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Prokineticin receptor 2: Wikis

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Prokineticin receptor 2
Identifiers
Symbols PROKR2; KAL3; PKR2; GPR73L1; GPR73b; GPRg2; dJ680N4.3
External IDs OMIM607123 MGI2181363 HomoloGene16368 IUPHAR: PKR2 GeneCards: PROKR2 Gene
RNA expression pattern
PBB GE PROKR2 gnf1h10315 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 128674 246313
Ensembl ENSG00000101292 ENSMUSG00000050558
UniProt Q8NFJ6 Q6GTF8
RefSeq (mRNA) NM_144773 NM_144944
RefSeq (protein) NP_658986 NP_659193
Location (UCSC) Chr 20:
5.23 - 5.24 Mb
Chr 2:
132.06 - 132.08 Mb
PubMed search [1] [2]

Prokineticin receptor 2 (PKR2), in a G-protein coupled receptor encoded by the PROKR2 gene in humans.[1]

Prokineticins are secreted proteins that can promote angiogenesis and induce strong gastrointestinal smooth muscle contraction. The protein encoded by this gene is an integral membrane protein and G protein-coupled receptor for prokineticins. The encoded protein is similar in sequence to GPR73, another G protein-coupled receptor for prokineticins.[1]

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Further reading

  • Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.  
  • Lin DC, Bullock CM, Ehlert FJ, et al. (2002). "Identification and molecular characterization of two closely related G protein-coupled receptors activated by prokineticins/endocrine gland vascular endothelial growth factor.". J. Biol. Chem. 277 (22): 19276–80. doi:10.1074/jbc.M202139200. PMID 11886876.  
  • Soga T, Matsumoto S, Oda T, et al. (2003). "Molecular cloning and characterization of prokineticin receptors.". Biochim. Biophys. Acta 1579 (2-3): 173–9. PMID 12427552.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Battersby S, Critchley HO, Morgan K, et al. (2004). "Expression and regulation of the prokineticins (endocrine gland-derived vascular endothelial growth factor and Bv8) and their receptors in the human endometrium across the menstrual cycle.". J. Clin. Endocrinol. Metab. 89 (5): 2463–9. doi:10.1210/jc.2003-032012. PMID 15126578.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Pasquali D, Rossi V, Staibano S, et al. (2006). "The endocrine-gland-derived vascular endothelial growth factor (EG-VEGF)/prokineticin 1 and 2 and receptor expression in human prostate: Up-regulation of EG-VEGF/prokineticin 1 with malignancy.". Endocrinology 147 (9): 4245–51. doi:10.1210/en.2006-0614. PMID 16763065.  
  • Dodé C, Teixeira L, Levilliers J, et al. (2006). "Kallmann syndrome: mutations in the genes encoding prokineticin-2 and prokineticin receptor-2.". PLoS Genet. 2 (10): e175. doi:10.1371/journal.pgen.0020175. PMID 17054399.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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