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Prolactin-releasing peptide receptor: Wikis


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Prolactin releasing hormone receptor
Symbols PRLHR; GPR10; GR3; MGC126539; MGC126541; PrRPR
External IDs OMIM600895 MGI2135956 HomoloGene3134 IUPHAR: PRRP GeneCards: PRLHR Gene
Species Human Mouse
Entrez 2834 226278
Ensembl ENSG00000119973 ENSMUSG00000045052
UniProt P49683 Q059H6
RefSeq (mRNA) NM_004248 NM_201615
RefSeq (protein) NP_004239 NP_963909
Location (UCSC) Chr 10:
120.34 - 120.34 Mb
Chr 19:
60.52 - 60.52 Mb
PubMed search [1] [2]

The prolactin-releasing hormone receptor (PRRP) is a G-protein coupled receptor[1] that binds the prolactin releasing hormone.[2]

PRLHR is a 7-transmembrane domain receptor for prolactin-releasing hormone (PRLH; MIM 602663) that is highly expressed in anterior pituitary (Ozawa et al., 2002).[supplied by OMIM][3]


  1. ^ Marchese A, Heiber M, Nguyen T, Heng HH, Saldivia VR, Cheng R, Murphy PM, Tsui LC, Shi X, Gregor P (1995). "Cloning and chromosomal mapping of three novel genes, GPR9, GPR10, and GPR14, encoding receptors related to interleukin 8, neuropeptide Y, and somatostatin receptors". Genomics 29 (2): 335–44. doi:10.1006/geno.1995.9996. PMID 8666380.  
  2. ^ Hinuma S, Habata Y, Fujii R, Kawamata Y, Hosoya M, Fukusumi S, Kitada C, Masuo Y, Asano T, Matsumoto H, Sekiguchi M, Kurokawa T, Nishimura O, Onda H, Fujino M (1998). "A prolactin-releasing peptide in the brain". Nature 393 (6682): 272–6. doi:10.1038/30515. PMID 9607765.  
  3. ^ "Entrez Gene: PRLHR prolactin releasing hormone receptor".  

Further reading

  • Hinuma S, Onda H, Fujino M (1999). "The quest for novel bioactive peptides utilizing orphan seven-transmembrane-domain receptors.". J. Mol. Med. 77 (6): 495–504. doi:10.1007/s001090050403. PMID 10475064.  
  • Marchese A, Heiber M, Nguyen T, et al. (1996). "Cloning and chromosomal mapping of three novel genes, GPR9, GPR10, and GPR14, encoding receptors related to interleukin 8, neuropeptide Y, and somatostatin receptors.". Genomics 29 (2): 335–44. PMID 8666380.  
  • Hinuma S, Habata Y, Fujii R, et al. (1998). "A prolactin-releasing peptide in the brain.". Nature 393 (6682): 272–6. doi:10.1038/30515. PMID 9607765.  
  • Fujii R, Fukusumi S, Hosoya M, et al. (1999). "Tissue distribution of prolactin-releasing peptide (PrRP) and its receptor.". Regul. Pept. 83 (1): 1–10. doi:10.1016/S0167-0115(99)00028-2. PMID 10498338.  
  • Langmead CJ, Szekeres PG, Chambers JK, et al. (2000). "Characterization of the binding of [(125)I]-human prolactin releasing peptide (PrRP) to GPR10, a novel G protein coupled receptor.". Br. J. Pharmacol. 131 (4): 683–8. doi:10.1038/sj.bjp.0703617. PMID 11030716.  
  • Lin SH, Arai AC, Wang Z, et al. (2001). "The carboxyl terminus of the prolactin-releasing peptide receptor interacts with PDZ domain proteins involved in alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor clustering.". Mol. Pharmacol. 60 (5): 916–23. PMID 11641419.  
  • Ozawa A, Yamada M, Satoh T, et al. (2002). "Transcriptional regulation of the human PRL-releasing peptide (PrRP) receptor gene by a dopamine 2 Receptor agonist: cloning and characterization of the human PrRP receptor gene and its promoter region.". Mol. Endocrinol. 16 (4): 785–98. doi:10.1210/me.16.4.785. PMID 11923475.  
  • Takahashi K, Totsune K, Murakami O, et al. (2003). "Expression of prolactin-releasing peptide and its receptor in the human adrenal glands and tumor tissues of adrenocortical tumors, pheochromocytomas and neuroblastomas.". Peptides 23 (6): 1135–40. doi:10.1016/S0196-9781(02)00046-3. PMID 12126742.  
  • Kemp DM, Lin JC, Ubeda M, Habener JF (2002). "NRSF/REST confers transcriptional repression of the GPR10 gene via a putative NRSE/RE-1 located in the 5' promoter region.". FEBS Lett. 531 (2): 193–8. doi:10.1016/S0014-5793(02)03502-0. PMID 12417311.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Bhattacharyya S, Luan J, Challis B, et al. (2003). "Association of polymorphisms in GPR10, the gene encoding the prolactin-releasing peptide receptor with blood pressure, but not obesity, in a U.K. Caucasian population.". Diabetes 52 (5): 1296–9. doi:10.2337/diabetes.52.5.1296. PMID 12716769.  
  • Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10.". Nature 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Ellacott KL, Donald EL, Clarkson P, et al. (2005). "Characterization of a naturally-occurring polymorphism in the UHR-1 gene encoding the putative rat prolactin-releasing peptide receptor.". Peptides 26 (4): 675–81. doi:10.1016/j.peptides.2004.11.020. PMID 15752583.  
  • Lagerström MC, Fredriksson R, Bjarnadóttir TK, et al. (2005). "Origin of the prolactin-releasing hormone (PRLH) receptors: evidence of coevolution between PRLH and a redundant neuropeptide Y receptor during vertebrate evolution.". Genomics 85 (6): 688–703. doi:10.1016/j.ygeno.2005.02.007. PMID 15885496.  
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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