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Prolintane
Systematic (IUPAC) name
1-(1-benzylbutyl)pyrrolidine
Identifiers
CAS number 493-92-5
ATC code N06BX14
PubChem 14592
Chemical data
Formula C15H23N 
Mol. mass 217.35 g/mol
Therapeutic considerations
Pregnancy cat.  ?
Legal status

Prolintane (Catovit) is a stimulant[1] which is closely related in chemical structure to other drugs such as pyrovalerone and with a similar mechanism of action, by inhibiting the reuptake of dopamine and other monoamine neurotransmitters. It is a mild stimulant with a good safety profile and relatively low incidence of cardiovascular problems or other side effects such as anorexia and insomnia, although these side effects may still occur at higher doses.[2] However, the good safety profile of this drug at low doses makes it suitable for use in elderly people to increase motivation and counteract the effects of senile dementia and age-related cognitive decline.[3] It is mainly used in European countries.

Prolintane may also be abused as a recreational stimulant and use for this purpose has reportedly been increasing in recent years.[4][5][6]

See also

References

  1. ^ Hollister LE, Gillespie HK. A new stimulant, prolintane hydrochloride, compared with dextroamphetamine in fatigued volunteers. Journal of Clinical Pharmacology and the Journal of New Drugs. 1970 Mar-Apr;10(2):103-9. PMID 4392006
  2. ^ Nicholson AN, Stone BM, Jones MM. Wakefullness and reduced rapid eye movement sleep: studies with prolintane and pemoline. British Journal of Clinical Pharmacology. 1980 Nov;10(5):465-72. PMID 7437258
  3. ^ Kuitunen T, Kärkkäinen S, Ylitalo P. Comparison of the acute physical and mental effects of ephedrine, fenfluramine, phentermine and prolintane. Methods and Findings in Experimental and Clinical Pharmacology. 1984 May;6(5):265-70. PMID 6471970
  4. ^ Payá B, Guisado JA, Vaz FJ, Crespo-Facorro B. Visual hallucinations induced by the combination of prolintane and diphenhydramine. Pharmacopsychiatry. 2002 Jan;35(1):24-5. PMID 11819155
  5. ^ Gaulier JM, Canal M, Pradeille JL, Marquet P, Lachâtre G. New drugs at "rave parties": ketamine and prolintane. (French). Acta Clinica Belgica. Supplementum. 2002;(1):41-6. PMID 11974443
  6. ^ Kyle PB, Daley WP. Domestic abuse of the European rave drug prolintane. Journal of Analytical Toxicology. 2007 Sep;31(7):415-8. PMID 17725890
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