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Propacetamol: Wikis

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Systematic (IUPAC) name
4-(acetamido)phenyl N,N-diethylglycinate
CAS number 66532-85-2
ATC code N02BE05
PubChem 68865
Chemical data
Formula C 14H2N2O3  
Mol. mass 264.3202 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life 2.4 hours [1]
Excretion Renal
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes IV[1][2]

Propacetamol is a prodrug form of paracetamol which is formed from esterification of paracetamol, and the carboxylic acid Diethylglycin. This has the advantage of making it more water soluble. It is used in post-operative care and is delivered by I.V.. [2] It is given if the patient is unable to take oral or rectally delivered paracetamol and non-steroidal anti-inflammatory drugs are contraindicated. The onset of analgaesia from propacetamol is more rapid than paracetamol given orally.[3] 2g of propacetamol are equivalent to 1g of paracetamol. [4]


  1. ^ a b Bannwarth B, Netter P, Lapicque F, Gillet P, Péré P, Boccard E, Royer RJ, Gaucher A (1992). "Plasma and cerebrospinal fluid concentrations of paracetamol after a single intravenous dose of propacetamol". Br J Clin Pharmacol 34 (1): 79–81. PMID 1633071.  
  2. ^ a b Binhas M, Decailliot F, Rezaiguia-Delclaux S, Suen P, Dumerat M, François V, Combes X, Duvaldestin P (2004). "Comparative effect of intraoperative propacetamol versus placebo on morphine consumption after elective reduction mammoplasty under remifentanil-based anesthesia: a randomized control trial [ISRCTN71723173"]. BMC Anesthesiol 4 (1): 6. doi:10.1186/1471-2253-4-6. PMID 15367329. Retrieved 2008-04-01.  
  3. ^ Moller PL, Sindet-Pedersen S, Petersen CT, Juhl GI, Dillenschneider A, Skoglund LA (2005). "Onset of acetaminophen analgesia: comparison of oral and intravenous routes after third molar surgery". Br J Anaesth 94 (5): 642–8. doi:10.1093/bja/aei109. PMID 15790675. Retrieved 2008-04-04.  
  4. ^ Flouvat B, Leneveu A, Fitoussi S, Delhotal-Landes B, Gendron A (2004). "Bioequivalence study comparing a new paracetamol solution for injection and propacetamol after single intravenous infusion in healthy subjects". Int J Clin Pharmacol Ther 42 (1): 50–7. PMID 14756388.  

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