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Propentofylline
Systematic (IUPAC) name
3-methyl-1-(5-oxohexyl)-7-propyl-3,7-dihydro-1 H-purine-2,6-dione
Identifiers
CAS number 55242-55-2
ATC code N06BC02
QC04AD90 QR03DA90
PubChem 4938
Chemical data
Formula C 15H22N4O3  
Mol. mass 306.360 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

Propentofylline (HWA 285) is a xanthine derivative with purported neuroprotective effects.

Contents

Pharmacology

It is a phosphodiesterase inhibitor.[1]

It also acts as an adenosine reuptake inhibitor.[1][2][3]

Uses

It is being studied as a possible treatment for Alzheimer's disease and multi-infarct dementia.[4][5]

Propentofylline has also been studied, to a lesser extent, as a possible adjunct in the treatment of ischemic stroke, due to its vasodilating properties.[6][7]

See also

References

  1. ^ a b Frampton M, Harvey RJ, Kirchner V (2003). "Propentofylline for dementia". Cochrane Database Syst Rev (2): CD002853. doi:10.1002/14651858.CD002853. PMID 12804440.  
  2. ^ Salimi S, Fotouhi A, Ghoreishi A, et al. (April 2008). "A placebo controlled study of the propentofylline added to risperidone in chronic schizophrenia". Prog. Neuropsychopharmacol. Biol. Psychiatry 32 (3): 726–32. doi:10.1016/j.pnpbp.2007.11.021. PMID 18096287. http://linkinghub.elsevier.com/retrieve/pii/S0278-5846(07)00411-3.  
  3. ^ Numagami Y, Marro PJ, Mishra OP, Delivoria-Papadopoulos M (June 1998). "Effect of propentofylline on free radical generation during cerebral hypoxia in the newborn piglet". Neuroscience 84 (4): 1127–33. PMID 9578400. http://linkinghub.elsevier.com/retrieve/pii/S0306-4522(97)00542-3.  
  4. ^ Frampton M, Harvey RJ, Kirchner V (2003). "Propentofylline for dementia". Cochrane database of systematic reviews (Online) (2): CD002853. doi:10.1002/14651858.CD002853. PMID 12804440.  
  5. ^ Kittner B, Rössner M, Rother M (1997). "Clinical trials in dementia with propentofylline". Ann. N. Y. Acad. Sci. 826: 307–16. PMID 9329701.  
  6. ^ Bath PM, Bath-Hextall FJ (2004). "Pentoxifylline, propentofylline and pentifylline for acute ischaemic stroke". Cochrane database of systematic reviews (Online) (3): CD000162. doi:10.1002/14651858.CD000162.pub2. PMID 15266424.  
  7. ^ Huber M, Kittner B, Hojer C, Fink GR, Neveling M, Heiss WD (1993). "Effect of propentofylline on regional cerebral glucose metabolism in acute ischemic stroke". J. Cereb. Blood Flow Metab. 13 (3): 526–30. PMID 8478410.  
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