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Prostaglandin E receptor 3: Wikis


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Prostaglandin E receptor 3 (subtype EP3)
Symbols PTGER3; EP3; EP3-I; EP3-II; EP3-III; EP3-IV; EP3e; MGC141828; MGC141829; MGC27302
External IDs OMIM176806 MGI97795 HomoloGene22622 IUPHAR: EP3 GeneCards: PTGER3 Gene
RNA expression pattern
PBB GE PTGER3 210375 at tn.png
PBB GE PTGER3 210374 x at tn.png
PBB GE PTGER3 210831 s at tn.png
More reference expression data
Species Human Mouse
Entrez 5733 19218
Ensembl ENSG00000050628 ENSMUSG00000040016
UniProt P43115 P30557
RefSeq (mRNA) NM_000957 NM_011196
RefSeq (protein) NP_000948 NP_035326
Location (UCSC) Chr 1:
71.09 - 71.29 Mb
Chr 3:
157.5 - 157.58 Mb
PubMed search [1] [2]

Prostaglandin E receptor 3, also known as EP3, is a prostaglandin receptor, encoded by the PTGER3 gene.[1]



The receptor is a member of the G-protein coupled receptor family. It is one of four receptors identified for prostaglandin E2 (PGE2). This receptor may have many biological functions, which involve digestion, nervous system, kidney reabsorption, and uterine contraction activities. In the stomach, it inhibits gastric acid secretions.

Studies of the mouse counterpart suggest that this receptor may also mediate adrenocorticotropic hormone response as well as fever generation in response to exogenous and endogenous stimuli.


Multiple alternatively spliced transcript variants encoding eight distinct isoforms have been reported.[1]

See also


External links

Further reading

  • Kotani M, Tanaka I, Ogawa Y, et al. (1995). "Molecular cloning and expression of multiple isoforms of human prostaglandin E receptor EP3 subtype generated by alternative messenger RNA splicing: multiple second messenger systems and tissue-specific distributions.". Mol. Pharmacol. 48 (5): 869–79. PMID 7476918.  
  • Duncan AM, Anderson LL, Funk CD, et al. (1995). "Chromosomal localization of the human prostanoid receptor gene family.". Genomics 25 (3): 740–2. PMID 7759114.  
  • Schmid A, Thierauch KH, Schleuning WD, Dinter H (1995). "Splice variants of the human EP3 receptor for prostaglandin E2.". Eur. J. Biochem. 228 (1): 23–30. PMID 7883006.  
  • An S, Yang J, So SW, et al. (1995). "Isoforms of the EP3 subtype of human prostaglandin E2 receptor transduce both intracellular calcium and cAMP signals.". Biochemistry 33 (48): 14496–502. PMID 7981210.  
  • Regan JW, Bailey TJ, Donello JE, et al. (1994). "Molecular cloning and expression of human EP3 receptors: evidence of three variants with differing carboxyl termini.". Br. J. Pharmacol. 112 (2): 377–85. PMID 8075855.  
  • Yang J, Xia M, Goetzl EJ, An S (1994). "Cloning and expression of the EP3-subtype of human receptors for prostaglandin E2.". Biochem. Biophys. Res. Commun. 198 (3): 999–1006. PMID 8117308.  
  • Kunapuli SP, Fen Mao G, Bastepe M, et al. (1994). "Cloning and expression of a prostaglandin E receptor EP3 subtype from human erythroleukaemia cells.". Biochem. J. 298 ( Pt 2): 263–7. PMID 8135729.  
  • Adam M, Boie Y, Rushmore TH, et al. (1994). "Cloning and expression of three isoforms of the human EP3 prostanoid receptor.". FEBS Lett. 338 (2): 170–4. PMID 8307176.  
  • Chang C, Negishi M, Nishigaki N, Ichikawa A (1997). "Functional interaction of the carboxylic acid group of agonists and the arginine residue of the seventh transmembrane domain of prostaglandin E receptor EP3 subtype.". Biochem. J. 322 ( Pt 2): 597–601. PMID 9065782.  
  • Kotani M, Tanaka I, Ogawa Y, et al. (1997). "Structural organization of the human prostaglandin EP3 receptor subtype gene (PTGER3).". Genomics 40 (3): 425–34. doi:10.1006/geno.1996.4585. PMID 9073510.  
  • Ushikubi F, Segi E, Sugimoto Y, et al. (1998). "Impaired febrile response in mice lacking the prostaglandin E receptor subtype EP3.". Nature 395 (6699): 281–4. doi:10.1038/26233. PMID 9751056.  
  • Bhattacharya M, Peri K, Ribeiro-da-Silva A, et al. (1999). "Localization of functional prostaglandin E2 receptors EP3 and EP4 in the nuclear envelope.". J. Biol. Chem. 274 (22): 15719–24. PMID 10336471.  
  • Liu J, Akahoshi T, Jiang S, et al. (2000). "Induction of neutrophil death resembling neither apoptosis nor necrosis by ONO-AE-248, a selective agonist for PGE2 receptor subtype 3.". J. Leukoc. Biol. 68 (2): 187–93. PMID 10947062.  
  • Kurihara Y, Endo H, Kondo H (2001). "Induction of IL-6 via the EP3 subtype of prostaglandin E receptor in rat adjuvant-arthritic synovial cells.". Inflamm. Res. 50 (1): 1–5. PMID 11235015.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Matsuoka Y, Furuyashiki T, Bito H, et al. (2003). "Impaired adrenocorticotropic hormone response to bacterial endotoxin in mice deficient in prostaglandin E receptor EP1 and EP3 subtypes.". Proc. Natl. Acad. Sci. U.S.A. 100 (7): 4132–7. doi:10.1073/pnas.0633341100. PMID 12642666.  
  • Wing DA, Goharkhay N, Hanna M, et al. (2003). "EP3-2 receptor mRNA expression is reduced and EP3-6 receptor mRNA expression is increased in gravid human myometrium.". J. Soc. Gynecol. Investig. 10 (3): 124–9. PMID 12699873.  
  • Abulencia JP, Gaspard R, Healy ZR, et al. (2003). "Shear-induced cyclooxygenase-2 via a JNK2/c-Jun-dependent pathway regulates prostaglandin receptor expression in chondrocytic cells.". J. Biol. Chem. 278 (31): 28388–94. doi:10.1074/jbc.M301378200. PMID 12743126.  
  • Richards JA, Brueggemeier RW (2003). "Prostaglandin E2 regulates aromatase activity and expression in human adipose stromal cells via two distinct receptor subtypes.". J. Clin. Endocrinol. Metab. 88 (6): 2810–6. PMID 12788892.  
  • Moreland RB, Kim N, Nehra A, et al. (2004). "Functional prostaglandin E (EP) receptors in human penile corpus cavernosum.". Int. J. Impot. Res. 15 (5): 362–8. doi:10.1038/sj.ijir.3901042. PMID 14562138.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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