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Prostaglandin F2alpha: Wikis


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Prostaglandin F2alpha
Systematic (IUPAC) name
(Z)-7-[(1R,2R,3 R,5S)-3,5-dihydroxy-2-[(E,3S)- 3-hydroxyoct-1-enyl]cyclopentyl]hept-5-enoic acid
CAS number 551-11-1 38562-01-5 (tromethamine)
ATC code G02AD01
PubChem 5280363
DrugBank DB01160
Chemical data
Formula C 20H34O5  
Mol. mass 354.48 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life 3 to 6 hours in amniotic fluid, less than 1 minute in blood plasma
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes Intravenous (to induce labor), intra-amniotic (to induce abortion)

Prostaglandin F (PGF in prostanoid nomenclature) is pharmaceutically termed Dinoprost (INN, is a naturally-occurring prostaglandin used in medicine to induce labor and as an abortifacient.

In domestic mammals, it is produced by the uterus when stimulated by oxytocin, in the event that there has been no implantation during the follicular phase. It acts on the corpus luteum to cause luteolysis, forming a corpus albicans and stopping the production of progesterone. Action of PGF is dependent on the number of receptors on the corpus luteum membrane.

Mechanism of action

PGF acts by binding to the prostaglandin F2α receptor.



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