The Full Wiki

More info on Protamine sulfate

Protamine sulfate: Wikis

  

Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.

Encyclopedia

From Wikipedia, the free encyclopedia

Protamine sulfate is a drug that reverses the anticoagulant effects of heparin by binding to it.

Protamine was originally isolated from the sperm of sharks and other species of fish but is now produced primarily through recombinant biotechnology. It is a highly cationic peptide. It binds to heparin to form a stable ion pair which does not have anticoagulant activity; on its own, protamine has a weak anticoagulant effect. The complex of heparin and protamine is then removed and broken down by the reticuloendothelial system.

Contents

Dosage

Dosage for heparin reversal is 1mg protamine sulfate i.v. for every 100 IU of active heparin. In patients who are allergic to fish, it can cause significant histamine release resulting in hypotension and bronchoconstriction, and also causes pulmonary hypertension. Infusion should be slow to minimize these side effects. In large doses, protamine itself has some anticoagulant effect.

Uses

Protamine sulfate is usually administered to reverse the large dose of heparin administered during certain surgeries, especially heart surgery. It is also used in gene transfer and protein purification. It is also used in tissue cultures as a crosslinker for viral transduction.

See also

References

External links








Got something to say? Make a comment.
Your name
Your email address
Message