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protoporphyrinogen oxidase
Symbol PPOX
Alt. symbols VP
Entrez 5498
HUGO 9280
OMIM 600923
RefSeq NM_000309
UniProt P50336
Other data
EC number
Locus Chr. 1 q22

Protoporphyrinogen oxidase (EC is an enzyme that is responsible for the seventh step in heme production. (Heme is the portion of hemoglobin that carries oxygen in the blood from the lungs to the rest of the body.)

Protoporphyrinogen oxidase removes hydrogen atoms from protoporphyrinogen IX (the product of the sixth step in the production of heme) to form protoporphyrin IX.

One additional enzyme must modify protoporphyrin IX before it becomes heme.

Heme synthesis—note that some reactions occur in the cytoplasm and some in the mitochondrion (yellow)

See also



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