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Protriptyline: Wikis


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Systematic (IUPAC) name
3-(5H-dibenzo[a,d][7]annulen-5-yl)- N-methylpropan-1-amine
CAS number 438-60-8
ATC code N06AA11
PubChem 4976
Chemical data
Formula C 19H21N 
Mol. mass 263.377 g/mol
Synonyms N-Methyl-5H-dibenzo[a,d]cycloheptene-5-propanamine
Pharmacokinetic data
Bioavailability  ?
Metabolism Hepatic
Half life 54–92 hours
Excretion Renal, in urine
Therapeutic considerations
Pregnancy cat. C(US)
Legal status Rx-only (US)
Routes Oral
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Protriptyline (Vivactil) is a tricyclic antidepressant (TCA), specifically a secondary amine, indicated for depression and ADHD. Unique among the TCAs, protriptyline tends to be energizing instead of sedating, and it is sometimes used in narcolepsy to achieve a wakefulness-promoting effect. (the other TCAs tend to be sedating and therefore are often taken in the evening)

TCAs including protriptyline are also used to reduce the incidence of recurring headaches such as migraine, and for other types of chronic pain. This drug can also be used for sleep apnea treatment along with a carbonic anhydrase inhibitor.

See also


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